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Extreme quadriceps starting pain after 3-4 rest days

Moderator: King Boonen

Re: Extreme quadriceps starting pain after 3-4 rest days

29 Nov 2018 12:03

[quote="But the best way to avoid the pain for me is to only rest one day. So if I have a resting-week on my trainingplan, I still go out every day and ride Zone 1 for an hour. I always stay in hotels that have a stationary bike. This is just how I have learnt to live with this problem.[/quote]

This is 100% me. A couple of months ago I came perilously close to an "attack" after 48 hours off the bike, but managed to just about keep it at bay by getting on the bike just in time (I could feel the "acid" (or whatever) rising but it never went nuclear); otherwise I've managed to keep it completely at bay by real careful management. It can be an incredible inconvenience though, especially with holidays, and thankfully my missus is a saint.


[quote="One the of the things that popped up on mine: "susceptibility to malignant hyperthermia (MHS) You may be at higher risk for a bad response to anesthetics."[/quote]

I'd be interested in giving this a go, just to help test your hypothesis. Which test did you do? The Health and Ancestry Svs or just the Health one?

Then was there any cost for the further analysis?
budegan
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Re: Extreme quadriceps starting pain after 3-4 rest days

08 Feb 2019 17:50

[quote="I'd be interested in giving this a go, just to help test your hypothesis. Which test did you do? The Health and Ancestry Svs or just the Health one?

Then was there any cost for the further analysis?[/quote]


I used 23andMe. You don't need to pay for the health report. You can just by the ancestry test and then download your raw file (a huge test file with your full DNA sequence). Running that raw file through promethease.com cost $12. I'll be interested to hear your results. Thanks!
barnes21bb
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Re: Extreme quadriceps starting pain after 3-4 rest days

12 Mar 2019 16:49

Drewza101 wrote:
Hypothesis
- the issue is an enzyme related issue in the muscles specifically related to the production of glycogen synthase.
- glycogen synthase is the enzyme which is responsible for converting glucose into glycogen for storage in muscle cells.
- in a "normal" person, during high load, levels of glycogen synthase increases in order to store fuel to meet the increased requirement for energy for the body. When exercise load decreases, the body automatically regulates the level of this enzyme as the body's need for stored glycogen reduces.
- the theory that we are working with is that in my case, the body is not regulating this enzyme level, and so the body is continuing to convert glucose into glycogen and packing it into the muscle cells.
- the problem is twofold in that firstly exercise has stopped and so the glycogen is not being used (but continues to be stored) and sugar and carb intake has not reduced (and often increased) so there is excess in the body and it is being stored.
- the theory is that the muscle cells get overloaded with glycogen and when exercise is introduced, the cells literally tear as a result of being overloaded.
- this accounts for the pain felt, as well as the increased CK levels.
- the hypothesis is that this is a genetic issue and there isn't a "cure" as such


I've got this StabbyLeg / LegAIDS problem, have had a few bouts over the years. Normally in reasonably heavy training that suddenly stops, often for a holiday that involves flights and/or lots of boozing, although I know other people who are non-drinkers that get it.

It's an interesting theory and I'm excited to try low-carb holidays to see if it makes any difference, but why does the problem only seem to happen to quadriceps if it's a whole-body muscle glycogen enzyme? Also, how come running up the stairs doesn't trigger the issue but gingerly walking down stairs will? That does seem to match the theory.
User avatar firsthippy
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Re: Extreme quadriceps starting pain after 3-4 rest days

14 Mar 2019 18:28

barnes21bb wrote:To test my hypothesis, is there anyone on this forum that has had DNA testing done? I know 23andME and Ancestry.com will let you download the raw data. It would interesting to see if anyone else on this forum comes back as MHS positive.

Interesting theory. I ran my 23andMe results through promothease, and when I search the report for malignant hyperthermia all the results that come up are green/good in my case.
jsk
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