I think Tockit said it pretty well. Constant denial. Then outside spin to discredit those who testify as having an axe to grind, hating him, etc. (think Besty Andreu, Greg Lemond, Mike Anderson, Emma O'Reilly, etc.), they'll also try to counter this bringing up the cyclists who contradicted these "haters" and take bullets for Lance. Then they'll bring up no hard evidence, spiced with more of the "most tested" and "never tested positive" and efforts to spin that.
As to criminal charges. Like, fraud, tax evasion, racketeering, or whatever else they try to stick to him, that he'll deflect to "I'm a cyclist, not a CEO" and "The only business dealings are for my cancer foundation to help cancer patients." If CEO and board members of mega corporations (Enron, WorldCom) that get busted for serious securities violations can plea ignorance, so can Lance.
But his general combative nature and hubris are not going to help him. When you get in this deep of a mess you want to come to it looking like the good victim who made a mistake, ask for forgiveness with hat in hand. There's no way he can do that. The evidence will be piled against him, and it's not in his nature, at all.
I still don't see him going to jail, or being essentially charged with doping. But I do see his reputation being fairly heavily tarnished by this, and people forever suspecting or assuming he doped through much of his career.