The wind will be NNW (850 hPa maps predict up to 20-25 kph) so unfortunately long fragments of substantial headwind in the last section. However, maybe the slope will partially protect riders from it (I guess NW or WNW would be worse here).
A lot depends on pacing in the first half of the climb but I think it will be strong: both UAE and Visma will be eager to have a go during this stage. I think Mayo's record will be beaten, top2 guys have incredible level. But it won't be as shattered as some poll options indicate. Prediction: 55'10'' by Pogacar.