Bagioli crashed on Sunday, unsure what the damage is though. Kron has marked this stage from the start, finish suits him very well. If not him, then the other Dane.
This heat will definitely have an impact. Roglic usually performs well in the heat, any GC contenders that tend to struggle with these temperatures? I know Wellens would DNF during the prologue already if he was here.
Valverde will likely have a great first (and a half or so) week to crumble after. Lot of finishes in that first week that work well for him, when it gets steeper though he'll definitely crack soon enough.