Aod-9604

[Catwhoorg]

See that latest WADA statement on a black market drug still in trial stages this one as an anti-obesity trials

Check the various bodybuilding forums for user reports on it from black market sources

Its a lipolytic section of HGH
http://www.ncbi.nlm.nih.gov/pubmed/11146367

 

[DirtyWorks]

I found research as early as 2002 on the drug.

Apparently, oral delivery does not appear to work. So, this would be some kind of topical delivery like an HGH patch maybe or some kind of injection.

WADA needs some interns to read body building forums to stay relatively current on these peptides.

 

[Catwhoorg]

WADA needs some interns to read body building forums to stay relatively current on these peptides.

Seriously!

 

[Tyler'sTwin]

What's the difference between this stuff and HGH?

 

[Catwhoorg]

I'm not that familiar with it, but from my reading it seems like it is similar to a portion of HGH in structure, and acts very similar to it in fat regulation only.

So good for weight loss, but without some of the serious side effects of HGH.


I have no idea if WADA have a test for it or not.

 

[serfla]

Lately, there have been some discussions on this forum about weight of some prominent riders . Now this.
Interesting coincidence.

I presume there isn't a test for it yet, since it's still in research phase. So it should be pretty safe for (ab)use.
If nothing else, WADA made a free commercial for it, so it's level playing field again.

 

[Hoary Marmot]

I used to do peptide synthesis for a living, and this one looks like it would be a piece of cake to make. A guy with some pretty basic and easily available precursors could make a killing synthesizing this stuff; it's like real life Breaking Bad, but PEDs instead of recreational drugs.
I wonder whether it has to have a biological 'scaffold' to carry it to the target cells. For such a small segment of the native protein, I'm surprised it could have an effect without being displayed in its usual context of the native protein structure.
I'm thinking it would be pretty tough to detect a peptide that small, even with mass spectroscopy methods. How does one clean up the sample without washing away a little 15-mer? Talk about a cellular needle in a haystack.

 

[blackcat]

I found research as early as 2002 on the drug.

Apparently, oral delivery does not appear to work. So, this would be some kind of topical delivery like an HGH patch maybe or some kind of injection.

WADA needs some interns to read body building forums to stay relatively current on these peptides.

livestrong second interns?

 

[DirtyWorks]

Lately, there have been some discussions on this forum about weight of some prominent riders . Now this.
Interesting coincidence.

I presume there isn't a test for it yet, since it's still in research phase. So it should be pretty safe for (ab)use.
If nothing else, WADA made a free commercial for it, so it's level playing field again.

If WADA is discussing it publicly, doping-wise it is in full circulation. There are more popular PED cocktails with peptides that lead to fat loss AND improved recovery than this.

It is also important to understand these aren't regulated compounds and not criminalized either. So, the worse possible outcome is you make some money selling it, then your national Food and Drug agency shuts you down.

I recommend visiting some body building forums where they discuss peptides. It's a doping revolution. No kidding.

 

[Hoary Marmot]

Post script to my prior posting - a further search on peptideman reveals a lot of satisfied customers on the muscle builder forums. Yikes.

 

[DirtyWorks]

I used to do peptide synthesis for a living, and this one looks like it would be a piece of cake to make. A guy with some pretty basic and easily available precursors could make a killing synthesizing this stuff; it's like real life Breaking Bad, but PEDs instead of recreational drugs.

For sure! It's legal until it isn't and it's not criminal to produce and sell until the regulators step in. (insert Evil Regulators Rap as seen on body building forums)

I hope you stick around and help fill in some of the peptide doping threads. I'm sure there are more coming.

 

[Zam_Olyas]

Body builders are nuts...ridiculous. vanities thy name are body builders.

 

[Catwhoorg]

I recommend visiting some body building forums where they discuss peptides. It's a doping revolution. No kidding.

Went there for information of GW501516. Saw a whole lot of other stuff. Was VERY eye opening.

In a lot of cases for these short chain peptides, the synthesis is ridiculously easy.

 

[L'arriviste]

Oh wow, more white label gear with an impossible-to-remember code. Though cheesy, the nickname the black marketeers are using for GW501516 ("Endurobol") is at least pretty easy to remember

Like Catwhoorg, I too have recently taken DirtyWorks' advice and dabbled in these fitness forums.

I was amazed at how these guys have totally assimilated dope into their routines, presumably because it's all good for pushing your body to its limits and looking 'ripped'.

A while back, I got a follow from that dude Millard Baker on Twitter and I couldn't understand his equivocal attitude but I'm starting to understand it now. They have a kind of relish for the experimentation and describe subcutaneous injections and mini doping programmes with what could only be described as infectious enthusiasm.

Strangely enough, instead of feeling depressed after reading an extraordinary amount of detail about GW105156 in the field - all given freely and helpfully - I felt oddly elated by the experience. Very positive.

 

[Benotti69]

I really hope someone in an accredited lab is keeping samples for later testing, but somehow I think that UCI is being very selective in whose saples are being kept and I doubt any Sky riders are.

 

[L'arriviste]

I really hope someone in an accredited lab is keeping samples for later testing, but somehow I think that UCI is being very selective in whose saples are being kept and I doubt any Sky riders are.

When interviewed recently, a representative of the lab at Cologne said the lab was able to keep samples for eight years per the SoL.

It was one of those responses on which a slightly sharper journo might have asked for clarification: has any sporting body instructed you to keep the samples then or are you just saying you could do that if required?

Sadly, that question was not asked, so we don't know for the moment.

 

[zigmeister]

I found research as early as 2002 on the drug.

Apparently, oral delivery does not appear to work. So, this would be some kind of topical delivery like an HGH patch maybe or some kind of injection.

WADA needs some interns to read body building forums to stay relatively current on these peptides.

ROFL. Wow, you know nothing about peptides and any GH related stuff huh?

A patch? Good one.

 

[ElChingon]

Body builders are nuts...ridiculous. vanities thy name are body builders.

But cyclist taking EPO, HGH, and who knows what else are?

 

[sittingbison]

its this exact drug that is the centre of the Australian football contretemps with the Cime Comission and ASADA. Its been freely administered for several years to Aussie Rules and Rugby League players in systematic programs endorsed by clubs (who are now pretending otherwise with weasel words)

 

[Ripper]

I found research as early as 2002 on the drug.

Apparently, oral delivery does not appear to work. So, this would be some kind of topical delivery like an HGH patch maybe or some kind of injection.

WADA needs some interns to read body building forums to stay relatively current on these peptides.

Seriously!

WADA should just hire Big Boat

 

[rata de sentina]

Apparently, oral delivery does not appear to work. So, this would be some kind of topical delivery like an HGH patch maybe or some kind of injection.

I share a lab with a group working on delivery of therapeutic peptides oral or transdermal delivery is a goal but not particularly successful. They would have to be injected.

WADA don't really need to be scanning for new compounds. As I understand it basically in this case if not licensed for human therapeutic use then it is banned under the code.

Section S0 of the prohibited list is a catch all:

Any pharmacological substance which is not addressed by any of the
subsequent sections of the List and with no current approval by any
governmental regulatory health authority for human therapeutic use (e.g
drugs under pre-clinical or clinical development or discontinued, designer
drugs, substances approved only for veterinary use) is prohibited at all
times.

The idea that if it is not on the list it is not banned is a crock.

 

[Catwhoorg]

Rata,

I think they need to keep abrest of whats going on not for banning purposes, as you rightly say they are covered under the catch alls..

But for test development, and understanding how people are taking them, be it cycles, for how long and dosages.

 

[Hematide]

Rata,

I think they need to keep abrest of whats going on not for banning purposes, as you rightly say they are covered under the catch alls..

But for test development, and understanding how people are taking them, be it cycles, for how long and dosages.

Remark also that WADA has been aware of these products for a much longer time than these press releases suggest. For example, Mario Thevis (connected to the cologne lab) PUBLISHED his test for GW-501516 in 2009.

I still think that a team team paying <100.000 €/year for unscrupulous pharmacologists and custom syntheses could do very interesting things without the public ever finding out.

BTW, nice to see some other people with experience in organic and peptide synthesis

 

[DirtyWorks]

Section S0 of the prohibited list is a catch all:

The idea that if it is not on the list it is not banned is a crock.

Good to see. I don't read the rules enough!

A minor point relevant to the compound in question and peptides in general is that none in the U.S. are criminalized. Too often I see references to some of these compounds as "black market" drugs and such when it is nothing of the kind.

At least in the U.S., eventually they are regulated, not criminalized, but in the meantime, there's plenty of demand for them.

 

[Tyler'sTwin]

I'm not that familiar with it, but from my reading it seems like it is similar to a portion of HGH in structure, and acts very similar to it in fat regulation only.

So good for weight loss, but without some of the serious side effects of HGH.


I have no idea if WADA have a test for it or not.

Which are?