Rsr13???

[ricara]

Someone told me about RSR13 many years ago. Apparently it works by bending the hemoglobin molecule slightly so that the oxygen is not bound so tightly and is more easily released to oxygen-deprived cells. I found a page from the NIH that says they have a test for it:

http://www.ncbi.nlm.nih.gov/pubmed/11746905

I did a search on the forums here and Dr. Maserati pointed out that it, along with any oxygen-boosting drug, was illegal under UCI rules. But I have two questions:

a) Does anybody know if UCI/WADA tests for RSR13?

b) Does anybody know how widespread the use of RSR13 is in cycling?

Thanks!

 

[Race Radio]

I remember hearing it was the next big thing about 10 years ago but little since.

 

[ricara]

Other Names

Yes, it has been around for quite a while. Apparently the FDA did not approve it for use within the US. The generic name is "efaproxiral", while the trade name in the US was to be "Efaproxyn" and the trade name outside the US was to be "Revaproxyn".

The UCI has a blanket ban against all blood boosting drugs, so this would be illegal. However, I don't know if anybody tests for it...

It was designed for cancer treatments:

"RSR13 (efaproxiral) is the first synthetic small molecule designed to "sensitize" hypoxic (oxygen-deprived) areas of tumors prior to radiation therapy by facilitating the release of oxygen from hemoglobin, the oxygen-carrying protein contained within red blood cells, and increasing the level of oxygen in tumors. The presence of oxygen in tumors is an essential element for the effectiveness of radiation therapy in the treatment of cancer."

It sure sounds like it would be effective at oxygenating any tissue. But since the FDA rejected approval back in 2004, I doubt it is available any more. It is possible that it was available on the black market eight to ten years ago. But everything hinges on whether or not it is tested for...

 

[python]

rsr 13 is certainly banned.

in facts it's doubly 'cursed' by wada - once as a blanket prohibition of enhanced oxygen transfer methods and then as a specific substance.

is it tested for now by the wada accredited labs ?

i don't have an up-to-date knowledge but it's not a huge challenge from the analytical chemistry stand point to develop a test. the molecule is small and well characterized. several mass spec based methods are suitable and probably are routinely used for screening.

rsr13 is similar to its well known natural relative 2,3-dpg.

is rsr13 currently used as a ped ?

again, there is no way to know for sure but the wisdom of using it is questionable. huge quantities are needed to produce noticeable rightward shift in the oxygen dissociation curve besides -- it's toxic.

it's my opinion that the drug whilst theoretically powerful indeed, is impractical.

 

[blackcat]

again, there is no way to know for sure but the wisdom of using it is questionable. huge quantities are needed to produce noticeable rightward shift in the oxygen dissociation curve besides -- it's toxic.

it's my opinion that the drug whilst theoretically powerful indeed, is impractical.

with the more esoteric peds, even growth, which is no longer esoteric, there is little research literature out there on specific ped qualities, since they contravene the ethics.

I think the developers do indeed occasionally seed some material into the athletics sphere to discern other potential. But asfaras applied research, we only got the anecdotal evidence for peds with athletes being experimental monkeys.

 

[blackcat]

sweet avatar python

 

[Anonymous]

BRJ Frs is the latest thing.It is very good.

 

[blackcat]

BRJ Frs is the latest thing.It is very good.

I aint tired of being tired

 

[ricara]

it's my opinion that the drug whilst theoretically powerful indeed, is impractical.

Thanks for the info, Python.

 

[Berzin]

So was this the undetectable drug of choice for Armstrong or was it the HemAssist?