Van der Poel can become the seventh rider to win the Ronde three times. He's the big favorite, but that also means the others will ride against him. He doesn't really have the team to control the race. His teammates will probably work to bring him to the second Kwaremont in a good position. In the final 55 km he should be strong enough to go alone. A big solo is a real possibility. When he goes full on one of those steep climbs, it's doubtful whether anyone can follow him.
Visma still has a strong duo with Jorgenson and Benoot, but they're not explosive on the climbs. Van Baarle has been ill, so he will probably just serve as a domestique, or as a distractor if they let him attack early.
Lidl-Trek has been decimated too. It's impossible to tell how Pedersen will perform four days after his crash. Skujins could be sent up the road, but I don't see him winning.
Groupama-FdJ is beginning to look like one of the strongest teams, with Küng, Madouas and Pithie. However they'd probably settle for a podium spot.
UAE has Wellens and Politt. Their shape is fine, but they haven't got a good record in the Tour of Flanders - only one top 10 place between the two of them.
Soudal-Q still looks weak, although Asgreen is showing signs of improvement. Or will we witness Alaphilippe's miraculous resurrection on Easter Day?
Other interesting outsiders are Bettiol, Lazkano and Turner. A strong group of second-tiers going solo might put MvdP under pressure to burn his matches too early, but the most likely outcome is that the Dutchman rolls them all up. In spite of everything this is still a race to look forward to.