All About Salbutamol

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What will the verdict in Froome's salbutamol case?

  • He will be cleared

    Votes: 43 34.1%
  • 3 month ban

    Votes: 4 3.2%
  • 6 month ban

    Votes: 15 11.9%
  • 9 month ban

    Votes: 24 19.0%
  • 1 year ban

    Votes: 16 12.7%
  • 2 year ban

    Votes: 21 16.7%
  • 4 year ban

    Votes: 3 2.4%

  • Total voters
    126
Aug 12, 2009
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Parker said:
Merckx index said:
As I noted before, Froome's teammate at Barlo, Steve Cummings, had a TUE for salbutamol.

Cummings was on the British track programme for many years

Merckx index said:
Even if salbutamol has only a minor effect, that's a nothing-to-lose situation. If it doesn't have an adverse effects, and it might help, why not use it?
It's clearly not a nothing to lose situation. What readings would do pills give. Isn't that the point of the threshold?


Merckx index said:
Of course not, nobody I know of has claimed that. Testosterone isn't the cornerstone of a doping program, either, not for cyclists, but it's still used. Salbutamol may
But lots of people have talked about taking testosterone as a performance enhancer. Nobody at all has mentioned taking salbutamol for anything but asthma.

Merckx index said:
Well, in the Lowe article linked upthread, it was described as "clearly done with a view to being seen." YMMV, but we know there are certain portions of a race where the leader will definitely be on the screen, and that's why it was observed. If he had been taking it for years on finishing climbs, it seems a little strange that no one ever noticed before. After the news broke, I don't recall a single journalist, rider or anyone else associated with cycling say, oh, of course, I've seen him puffing away before.
What did you think he should do? Drop back down the bunch and hide behind people. No-one had seen him puffing away before because they weren't looking for it. It barely looks any different to someone eating something.

Merckx index said:
Beyond that, your question, of course, applies just as much to scenarios in which Froome was not intentionally doping. If he accidentally took too much, how could that happen after all this time? It also applies to random chance theories: how could one test be so much higher than all the others?
Precisely my point. But a person who knows they are doing something wrong will always be more cautious.

The most rational explanation is that he overdid his asthma drugs and/or the test isn't perfect (probably a combination of both). Not that he had some sort of overarching scheme plotted over many years to abuse an ineffective drug that no-one else has ever bothered with before.

I know you really, really want this to be a proper doping scandal, but I'm pretty sure you'll be disappointed.

to the bolded...I'm not sure you are following the same 'doping' case as the reast of us...the allegation only relates to its treatment for asthma as Froome (allegedly) has asthma...it would be being taken for its other performance enhancing properties....or on the day in question it was taken by mistake orally assumed to be sometjhing else...2000 does not relate to puffs for asthma...unless of course you believe Froome..... 2+2 does not equal 2000 however much you might want to believe it does...keep on believin' hold onto that feelin' ;)
 
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gillan1969 said:
.2000 does not relate to puffs for asthma...unless of course you believe Froome..... 2+2 does not equal 2000 however much you might want to believe it does...keep on believin' hold onto that feelin' ;)
You say this with absolute certainty (despite having specialized no knowledge of the subject). If it was an absolute certainty why are people in this situation submitted to further testing?
 
Aug 12, 2009
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Parker said:
gillan1969 said:
.2000 does not relate to puffs for asthma...unless of course you believe Froome..... 2+2 does not equal 2000 however much you might want to believe it does...keep on believin' hold onto that feelin' ;)
You say this with absolute certainty (despite having specialized no knowledge of the subject). If it was an absolute certainty why are people in this situation submitted to further testing?

people with above the threshold have the opportunity to "show their working" in order to achieve their own particular result...Froome was offered the opportunity to to say he inadvertently inputed 1998 into the calculator instead of 2...however he maintained he put 2 in. As MI has pointed out, with some well thought out scenarios...if Froome had taken a different approach he might have been able to explain away a figure above 1200 but quite far below 2000 but would have needed to acknowledge he could have made a mistake.....

but he never..............
 
Aug 12, 2009
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Parker said:
gillan1969 said:
.2000 does not relate to puffs for asthma...unless of course you believe Froome..... 2+2 does not equal 2000 however much you might want to believe it does...keep on believin' hold onto that feelin' ;)
You say this with absolute certainty (despite having specialized no knowledge of the subject). If it was an absolute certainty why are people in this situation submitted to further testing?

reminds of the other sky rider explaining things away...it wasn't so much the 32 units that was unbelievable...it was not drinking water at all the next day :) ...but when you need to get a certain number you need to try anything to get there....
 
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Parker said:
Cummings was on the British track programme for many years

But he wasn’t when he was at Barloworld, was he?

Look, maybe there’s an explanation for why FB didn’t find a TUE for salbutamol for Froome. Or why Froome, when asked, said those prednisolone TUEs were the only ones he ever had. I’m putting this out because it’s obviously very germane to this case, and I’m frankly mystified why no one in the media cares. Just as no one in the media cared about his USG, when that one value had the potential to get Froome off immediately, case closed. You seem content that there might be an explanation for this, so aren't interested in pursuing it any further. I’m not. I want to know for sure.

It's clearly not a nothing to lose situation. What readings would do pills give. Isn't that the point of the threshold?

It’s not that difficult to take oral doses and remain below the threshold. I’ve discussed this before.

But lots of people have talked about taking testosterone as a performance enhancer. Nobody at all has mentioned taking salbutamol for anything but asthma.

What riders talk about, and are actually heard talking about, is not the ultimate arbiter of whether something is performance enhancing. There are many studies showing salbutamol can help, and of course the existence of a threshold implies WADA takes this possibility seriously.

What did you think he should do? Drop back down the bunch and hide behind people. No-one had seen him puffing away before because they weren't looking for it. It barely looks any different to someone eating something.

So after seven years or so as a pro, and several years at the top, Froome is seen inhaling. Not only has the most-watched rider in the peloton never been seen doing this before, but none of his teammates or other riders in the peloton came forward to confirm that he’s been doing this.

Precisely my point. But a person who knows they are doing something wrong will always be more cautious.

Like Ricco?

The most rational explanation is that he overdid his asthma drugs and/or the test isn't perfect (probably a combination of both). Not that he had some sort of overarching scheme plotted over many years to abuse an ineffective drug that no-one else has ever bothered with before.

I really don’t think one can claim at this point that there is a “most rational” explanation, not with the certainty implied by your claim. There’s too much information we don’t have access to. And I'm not sure what you mean by the test isn't perfect. It certainly measures urinary concentration of salbutamol with high precision, so there's no reason at all to doubt the level reported. Like any pharmacological test, there is some uncertainty in working backward from there to dose taken.

If Froome were a little over the threshold, and he admitted he might have taken too much, I would certainly be inclined to accept that as the most likely explanation, though even then I wouldn’t rule out doping. The threshold has been set at a level that for most athletes, most of the time, is well above what they will test at. Unless Froome is an outlier, he probably wouldn’t exceed it even slightly unless he took considerably more than allowed.

But his level is so high that it’s hard to see how he could have reached it without taking a massive dose. Many researchers believe the most likely cause is that he intentionally did this, probably through a nebulizer. Again, if he admitted to doing that, I would give him the benefit of the doubt.

But Froome has said over and over and over that he didn’t inhale too much. At a certain point, I think you have to take him at his word—not assume he’s telling the truth, but that this is the framework within which a decision has to be made. And that means you have to compare the likelihood of doping to the likelihood of some unusual physiology, like renal impairment. Made a mistake is off the table. That's why doping, despite some reasonable objections, looks to be the more likely answer. We know riders dope. Kidney problems are unusual.

But if you want to stick with the notion that he took too much by mistake or accident, you're basically saying Froome is a liar. That makes you more or less just like anyone who thinks he was doping, you're just focusing on a different kind of lie. But lying and cheating are close cousins, and if someone would lie about taking too much salbutamol, it's difficult to trust anything else he says related to potential doping.

I know you really, really want this to be a proper doping scandal, but I'm pretty sure you'll be disappointed.

I’m always amused when someone accuses me, a scientist, of being more biased than he is. In the past, I've taken flak from fans of riders like Tyler, Floyd, LA and Contador because I pointed out how science undermined their defense.

I’m trying to understand what happened, and though I’ve long thought Froome was a doper, that suspicion doesn’t compromise my ability to think rationally and based on facts. In the very beginning of this thread I shot down the blood contamination hypothesis—a notion that obviously would appeal to anyone who thinks Froome is doping—because it was clearly highly improbable. As I noted above, I’ve also puzzled over the fact that salbutamol is not a drug that one would expect a rider to take during a race. I’ve never maintained that there is an obvious explanation for the positive, particularly when I’m not privy to some of the most important data that could shed more light on Froome’s usage of the drug.

Robert5091 said:

This was discussed upthread. Most researchers don't believe this is possible, though there has been some recent work suggesting that riders can lose as much as 2% of body weight (this would correspond to that 47 seconds up Alpe) through dehydration without compromising power.
 
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WADA director of Science Oliver Rabin discusses nebulization and the anabolic effects of Salbutamol

‘We have an upper limit because we have multiple publications showing that systemic use of beta-2 agonists, including salbutamol, can be performance enhancing,’ Rabin explains.

‘It’s not the medical practice that we’re trying to control, it’s fundamentally that beta-2 agonists can be performance enhancing in high doses,’ says Rabin.

Dr Hull suggested that this (nebulization) could become more common as teams ‘opt to avoid using an oral corticosteroid (ie, to prevent accusation of use for performance gain).’

http://www.cyclist.co.uk/news/4053/salbutamol-can-be-performance-enhancing-says-wada
 
Feb 16, 2010
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Re:

70kmph said:
WADA director of Science Oliver Rabin discusses nebulization and the anabolic effects of Salbutamol

‘We have an upper limit because we have multiple publications showing that systemic use of beta-2 agonists, including salbutamol, can be performance enhancing,’ Rabin explains.

‘It’s not the medical practice that we’re trying to control, it’s fundamentally that beta-2 agonists can be performance enhancing in high doses,’ says Rabin.

Dr Hull suggested that this (nebulization) could become more common as teams ‘opt to avoid using an oral corticosteroid (ie, to prevent accusation of use for performance gain).’

http://www.cyclist.co.uk/news/4053/salbutamol-can-be-performance-enhancing-says-wada

thanks for the link
v.informative article
 
Sep 27, 2017
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Merckx index said:
Parker said:
Cummings was on the British track programme for many years

But he wasn’t when he was at Barloworld, was he?

Look, maybe there’s an explanation for why FB didn’t find a TUE for salbutamol for Froome. Or why Froome, when asked, said those prednisolone TUEs were the only ones he ever had. I’m putting this out because it’s obviously very germane to this case, and I’m frankly mystified why no one in the media cares. Just as no one in the media cared about his USG, when that one value had the potential to get Froome off immediately, case closed. You seem content that there might be an explanation for this, so aren't interested in pursuing it any further. I’m not. I want to know for sure.

It's clearly not a nothing to lose situation. What readings would do pills give. Isn't that the point of the threshold?

It’s not that difficult to take oral doses and remain below the threshold. I’ve discussed this before.

But lots of people have talked about taking testosterone as a performance enhancer. Nobody at all has mentioned taking salbutamol for anything but asthma.

What riders talk about, and are actually heard talking about, is not the ultimate arbiter of whether something is performance enhancing. There are many studies showing salbutamol can help, and of course the existence of a threshold implies WADA takes this possibility seriously.

What did you think he should do? Drop back down the bunch and hide behind people. No-one had seen him puffing away before because they weren't looking for it. It barely looks any different to someone eating something.

So after seven years or so as a pro, and several years at the top, Froome is seen inhaling. Not only has the most-watched rider in the peloton never been seen doing this before, but none of his teammates or other riders in the peloton came forward to confirm that he’s been doing this.

Precisely my point. But a person who knows they are doing something wrong will always be more cautious.

Like Ricco?

The most rational explanation is that he overdid his asthma drugs and/or the test isn't perfect (probably a combination of both). Not that he had some sort of overarching scheme plotted over many years to abuse an ineffective drug that no-one else has ever bothered with before.

I really don’t think one can claim at this point that there is a “most rational” explanation, not with the certainty implied by your claim. There’s too much information we don’t have access to. And I'm not sure what you mean by the test isn't perfect. It certainly measures urinary concentration of salbutamol with high precision, so there's no reason at all to doubt the level reported. Like any pharmacological test, there is some uncertainty in working backward from there to dose taken.

If Froome were a little over the threshold, and he admitted he might have taken too much, I would certainly be inclined to accept that as the most likely explanation, though even then I wouldn’t rule out doping. The threshold has been set at a level that for most athletes, most of the time, is well above what they will test at. Unless Froome is an outlier, he probably wouldn’t exceed it even slightly unless he took considerably more than allowed.

But his level is so high that it’s hard to see how he could have reached it without taking a massive dose. Many researchers believe the most likely cause is that he intentionally did this, probably through a nebulizer. Again, if he admitted to doing that, I would give him the benefit of the doubt.

But Froome has said over and over and over that he didn’t inhale too much. At a certain point, I think you have to take him at his word—not assume he’s telling the truth, but that this is the framework within which a decision has to be made. And that means you have to compare the likelihood of doping to the likelihood of some unusual physiology, like renal impairment. Made a mistake is off the table. That's why doping, despite some reasonable objections, looks to be the more likely answer. We know riders dope. Kidney problems are unusual.

But if you want to stick with the notion that he took too much by mistake or accident, you're basically saying Froome is a liar. That makes you more or less just like anyone who thinks he was doping, you're just focusing on a different kind of lie. But lying and cheating are close cousins, and if someone would lie about taking too much salbutamol, it's difficult to trust anything else he says related to potential doping.

I know you really, really want this to be a proper doping scandal, but I'm pretty sure you'll be disappointed.

I’m always amused when someone accuses me, a scientist, of being more biased than he is. In the past, I've taken flak from fans of riders like Tyler, Floyd, LA and Contador because I pointed out how science undermined their defense.

I’m trying to understand what happened, and though I’ve long thought Froome was a doper, that suspicion doesn’t compromise my ability to think rationally and based on facts. In the very beginning of this thread I shot down the blood contamination hypothesis—a notion that obviously would appeal to anyone who thinks Froome is doping—because it was clearly highly improbable. As I noted above, I’ve also puzzled over the fact that salbutamol is not a drug that one would expect a rider to take during a race. I’ve never maintained that there is an obvious explanation for the positive, particularly when I’m not privy to some of the most important data that could shed more light on Froome’s usage of the drug.

Robert5091 said:

This was discussed upthread. Most researchers don't believe this is possible, though there has been some recent work suggesting that riders can lose as much as 2% of body weight (this would correspond to that 47 seconds up Alpe) through dehydration without compromising power.

Excellent and well balanced post MI. Difficult to argue with any of what you say when presented in that matter.
 
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Claiming the testing isnt perfect is ludicrous....there are 10000 Sal tests per annum, only a few at 1000, and only one at 2000

Dawg has repeatedly stated he only took a legal dose via inhaler. So no accidental overdose, or pills etc

Go read a bodybuilder forum , or even the XC ski one here to see discussion about Sal as a PED
 
Mar 29, 2016
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sittingbison said:
Claiming the testing isnt perfect is ludicrous....there are 10000 Sal tests per annum, only a few at 1000, and only one at 2000

Dawg has repeatedly stated he only took a legal dose via inhaler. So no accidental overdose, or pills etc

Go read a bodybuilder forum , or even the XC ski one here to see discussion about Sal as a PED

Sky's lawyers will try to find doubt, inaccuracies, human error, sloppy routines, anything to cast doubt on the test. Sky have to find only one mess up with a sample to throw some mud (maybe Cookson can help them out there?) Throw in an "infected procedure" due to a leak, that might well have come from the UCI because of a possible anti-British bias and suddenly, Froome's the victim! Wow! :surprised:
 
Jul 27, 2010
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70kmph said:
WADA director of Science Oliver Rabin discusses nebulization and the anabolic effects of Salbutamol

From this article:

if someone were admitted to hospital in the UK with a severe exacerbation (an asthma attack), the patient might expect a 2,500 microgram dosage every two hours – far exceeding the WADA maximum. This would generally be done with nebulisation, where a high volume of salbutamol in aerosol form is inhaled through a mask. A cyclist could require this dosage in the event of a serious attack and in such cases an athlete could be granted a TUE even after the incident.

That seems to rule out the theory, supposedly favored by most researchers familiar with asthma and salbutamol, that Froome took a supra-maximal dose for medical reasons, and lied about it. We’ve already discussed why Froome’s all-or-none strategy is necessary to optimize the chances of any explanation he comes up with being accepted. To this I think we can add this possibility of a TUE after the fact, something I hadn’t been aware of till now. If he had taken a massive dose via nebulizer, it seems he could have obtained the TUE, so he clearly didn’t. At the very least, the possibility of getting a TUE would certainly be a strong point in arguing for no sanction. Sundby admitted to using a nebulizer, and even on WADA's appeal, he only got two months.

The only other option for Froome would be to claim he took a few extra puffs. Not only could he not get a TUE on that basis, but a few extra puffs would be unlikely to account for his urine level, anyway. That strategy did work for Ulissi—he got a relatively light suspension—but I don’t think it’s a sure thing for someone with a urine level that high. If he made that claim, I think the response might be, you must have taken a lot of extra puffs, and if you needed that much salbutamol, you must have had a very severe attack, why didn’t you use a nebulizer?

In the Sundby case--which is likely to come up during the hearing--the athlete in a controlled lab test took 1600 ug in a half hour period, and still did not reach 2000 ng/ml. A few subjects in some studies have exceeded 2000 ng/ml following 1600 ug, but they're fairly uncommon (about 4% of the samples in the oft-referred to Haase study that investigated exercise and dehydration), so the prosecution could argue that to get to that level, Froome couldn't have been unaware that he was exceeding the allowed amount.

So Froome's all-or-nothing strategy is beginning to look to me less like a bold if not reckless gamble, and more the result of necessity. I don't think his team can have a lot of confidence that admitting to a mistake would get him a light sentence, just because it worked in the past. More data from lab studies are available now, and while they do suggest that outliers can exceed the WADA threshold without taking more than the allowed amount, they also show that values well above threshold in the great majority of cases require far more than the allowed amount. Might as well be hung for a sheep as a goat.
 
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Re: Re:

ClassicomanoLuigi said:
"if you needed that much salbutamol [in order to ride nonstop for five hours over three categorized climbs, then drop noted climber Vincenzo Nibali by 21 seconds], you must have had a very severe attack!"

Which actually might be the answer to why someone would take salbutamol during a GT. One possibility is the evidence that it could aid recovery. But a better-documented effect is an increase in anaerobic power. When does a GT rider need anaerobic power? During an attack on a climb. To drop an elite climber like Nibs requires a severe attack. Salbutamol might indeed by used for severe attacks!
 
Mar 29, 2016
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Servere attacks indeed - almost Landis like recovery after the previous day. But the question remains though, why take so much if, as race leader he knew he would get tested at the finish?

Edit - Froome getting a lighter sentence because of possible bias, might be enhanced by him riding this Summer and getting booed and covered in urine at every event. Just think of last years TdF ... "I'm the victim here!"
 
Feb 16, 2010
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Robert5091 said:
Servere attacks indeed - almost Landis like recovery after the previous day. But the question remains though, why take so much if, as race leader he knew he would get tested at the finish?

Edit - Froome getting a lighter sentence because of possible bias, might be enhanced by him riding this Summer and getting booed and covered in urine at every event. Just think of last years TdF ... "I'm the victim here!"
The Cookson Jolly was still in play
 
Jul 19, 2009
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Robert5091 said:
Servere attacks indeed - almost Landis like recovery after the previous day. But the question remains though, why take so much if, as race leader he knew he would get tested at the finish?
Because they had a plan to beat the doping test and something went wrong!
 
Jun 20, 2015
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Any subsequent case heard at CAS after a hearing at an Anti-Doping Tribunal is always a 'DE Novo' case which means a completely new trial - So in other words fresh evidence and tactics.
 
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Re: Re:

Merckx index said:
If he made that claim, I think the response might be, you must have taken a lot of extra puffs, and if you needed that much salbutamol, you must have had a very severe attack, why didn’t you use a nebulizer?

That's assuming they had one to hand though, are nebulizers regularly carried by teams ? How big / portable are they ?
 

thehog

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A new one from Walsh, apparently the kidneys “stores” Salbutamol after a taking antisbiotic :confused: or the kidneys stored the Salbutamol and the antibiotics caused the “dump” of Sal into the blood stream.

Firstly the kidney is a filter not a storage unit of the body. And this is new, why was Froome taking antibiotics? :cool:

mjxriv.jpg
 
Aug 12, 2009
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thehog said:
A new one from Walsh, apparently the kidneys “stores” Salbutamol after a taking antisbiotic :confused: or the kidneys stored the Salbutamol and the antibiotics caused the “dump” of Sal into the blood stream.

Firstly the kidney is a filter not a storage unit of the body. And this is new, why was Froome taking antibiotics? :cool:

mjxriv.jpg

this should be easily replicated in the lab then....

unless of course, it's just a red herring to help massage the Froome fans and keep them onside for his post-ban career and will never be tested by court/tribunal/panel...that's the usual SKY MO
 
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Re: Re:

bigcog wrote

That's assuming they had one to hand though, are nebulizers regularly carried by teams ? How big / portable are they ?

Sir David said: 'I believe it is for loosening mucus, quite often the guys if they get a tight chest will use a nebuliser. It's a product we use in there.'

http://www.dailymail.co.uk/news/article-4048564/Team-Sky-boss-Sir-David-Brailsford-FINALLY-reveals-medical-package-sent-treat-Bradley-Wiggins-telling-MPs-decongestant-fluimucil.html
 
May 11, 2013
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thehog said:
A new one from Walsh, apparently the kidneys “stores” Salbutamol after a taking antisbiotic :confused: or the kidneys stored the Salbutamol and the antibiotics caused the “dump” of Sal into the blood stream.

Firstly the kidney is a filter not a storage unit of the body. And this is new, why was Froome taking antibiotics? :cool:

mjxriv.jpg

This is comedy gold. Froome's "crazy adaptive physiology" allows his kidneys to store different things like in this case salbutamol for a few days, maybe weeks, who knows? In order to store certain substances the kidneys have to "malfunction" but "not fully" because otherwise any human would be in hospital with his family praying for him. Then, at some point the kidneys decide to dump into his system a massive amount of salbutamol which Froome has been taking for days, maybe weeks, who knows? On top of it he needs antibiotics but not for the kidneys but for bronchitis. This is something Walsh forgot to mention but Matteo Tosatto did here, on Jan 8th:

http://tribunatreviso.gelocal.it/sport/2018/01/08/news/toso-in-ammiraglia-sky-apre-la-strada-a-froome-1.16328324

"In those days, he was not well. He had bronchitis and took antibiotics."
 
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thehog said:
A new one from Walsh, apparently the kidneys “stores” Salbutamol after a taking antisbiotic :confused: or the kidneys stored the Salbutamol and the antibiotics caused the “dump” of Sal into the blood stream.

Firstly the kidney is a filter not a storage unit of the body. And this is new, why was Froome taking antibiotics? :cool:

mjxriv.jpg

got to love the sheer level of BS...."It has been said that he believes...." :lol:
 

thehog

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gillan1969 said:
thehog said:
A new one from Walsh, apparently the kidneys “stores” Salbutamol after a taking antisbiotic :confused: or the kidneys stored the Salbutamol and the antibiotics caused the “dump” of Sal into the blood stream.

Firstly the kidney is a filter not a storage unit of the body. And this is new, why was Froome taking antibiotics? :cool:

mjxriv.jpg

got to love the sheer level of BS...."It has been said that he believes...." :lol:

I love how Walsh begins with “It has been said” like it’s some form of popular thinking that Salbutamol is stored for weeks on end in the kidneys, rather than Walsh just being a paid shill again :lol:
 

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