I think Jungels is going to be a big loss for QS in more than just his own racing ability. In the QS behind the scenes videos of this year's races, after the DS speaks on the team bus about the day's race to come, it's always Jungels speaking up to reiterate the important parts and add his own observations and encouragement. No matter whether a classic, a sprint stage or a mountain stage, when he speaks, a bigger star like Alaphilippe listens to him, and a more experienced guy like Styby listens to him.
Problem with the route is that Jungels is not a top 10 climber in this Giro field on any Cat 1 climb and the Giro has basically 4 of the 4 hardest mountain stages this year. I don't see any point of Jungels riding the Giro. He is a solid contender for LBL or he could be pivotal in helping Alaphilippe winning it, thus returning the favor of last year.
No way Ala would be the biggest favorite.
You will usually find in any given year 2 or 3 strong climbers for the win. That year was Nibali, last year was Pinot. 2 years ago we had Chaves, Urán and Rosa. Any climber or group of Climbers with Ala in the group will try very hard to drop him before the finish.