I don't think this will be as dominant a win for MVDP as you would expect. Look at 2022 Roubaix for example when Van Baarle took a shock win and MVDP was nowhere. And in 2021 Flanders when Asgreen won. And even last weekend when Pedersen outsprinted him. And 2021 Roubaix when Colbrelli and Vermeersch outsprinted him. Even last year, had Pogi not been in the race the winner probably would have come from that huge breakaway. I reckon others will be close to him. I think he will only win one of Flanders and Roubaix and we will see some surprise names competing - yes it's sad that Wout isn't here but there are still a lot of good riders here and a lot can happen in these cobbled races. Not having Pogi arguably adds to the unpredictability as we all know how he will race and he would drop all the second-tier contenders, but having them still in the front group means more chaos! I reckon Mohoric could be a serious contender. Michael Matthews will also be up here after almost outsprinting Phillipsen in MSR. Bettiol looked super strong but maybe the distance is too much for him. Pedersen is the number 2 favourite. But even riders in the early break can have a big influence, as we saw on Wednesday
While I don't think that Van der Poel will have a win as dominant as Pogačar had in Strade or he himself had in E3, I am still confident that he will get the win in Flanders
Out of the examples that you gave, I think only 2021 RVV is a good example and Van der Poel still come second in that race against an Asgreen that was arguably the strongest and Van der Poel is a stronger rider than he was in 2021 so even if he doesn't win I would be very surprised if there is another rider stronger than him. Gent-Wevelgem has a much easier parcours than Flanders and Lidl-Trek played their carda perfectly against a Van der Poel that was likely not totally recovered from his solo in E3. Now, its Pedersen who will have to recover of his crash in DDV so the odds are against him.
I think the biggest danger for Van der Poel is if riders like Jorgenson, Wellens or Bettiol try to anticipate, likely before the first Oude Kwaremont-Paterberg combo. But, I don't think Van der Poel will give these kind of riders too much of a leash if any.
Now, Roubaix is a different story and the odds of Van der Poel winning there are obviously lower but Philipsen will be a second very strong card that Alpecin can play there.