General Doping Thread.

[rokovski]

There is article about freediving record, could be breathing high level oxygen before start of short time trial beneficial?

 

[Sciatic]

There is article about freediving record, could be breathing high level oxygen before start of short time trial beneficial?

Don't know -- but it wouldn't be UCI legal?

 

[Tim Cahill]

Don't know -- but it wouldn't be UCI legal?

I assumed so too after the rumours around the rebreathers and Sky's alleged noble gas method back in the day, but apparently not;

M1.2. Artificially enhancing the uptake, transport or delivery of oxygen. Including, but not limited to: Perfluorochemicals; efaproxiral (RSR13); voxelotor and modified haemoglobin products, e.g. haemoglobin-based blood substitutes and microencapsulated haemoglobin products, excluding supplemental oxygen by inhalation.

• What is the status of supplemental oxygen?​

  
  Supplemental oxygen administered by inhalation, but not intravenously, is permitted. However, some sports authorities may prohibit its use in their regulations. Athletes must check the rules that apply to supplemental oxygen use with the sporting authorities governing the events they compete in.
  
  
  

 

[Sciatic]

I assumed so too after the rumours around the rebreathers and Sky's alleged noble gas method back in the day, but apparently not;

M1.2. Artificially enhancing the uptake, transport or delivery of oxygen. Including, but not limited to: Perfluorochemicals; efaproxiral (RSR13); voxelotor and modified haemoglobin products, e.g. haemoglobin-based blood substitutes and microencapsulated haemoglobin products, excluding supplemental oxygen by inhalation.

• What is the status of supplemental oxygen?​

  
  Supplemental oxygen administered by inhalation, but not intravenously, is permitted. However, some sports authorities may prohibit its use in their regulations. Athletes must check the rules that apply to supplemental oxygen use with the sporting authorities governing the events they compete in.
  
  

Would be hard to believe it's allowable right before a race in pro cycling. Based on the above (if allowed) why don't we see riders get hits of O2 from team cars on climbs during the race (a' la NFL sidelines)?

 

[Unchained]

Would be hard to believe it's allowable right before a race in pro cycling. Based on the above (if allowed) why don't we see riders get hits of O2 from team cars on climbs during the race (a' la NFL sidelines)?

What good would it do? The absorption through your lungs is a natural limiter..would be sort of cool to see riders wearing a canula or facemask.. Oxygen tank, maybe a....

View: https://m.youtube.com/watch?v=qnGTCgHGruM&pp=ygUYbWluaSBveHlnZW4gY29uY2VudHJhdG9y


Amgen and a few others already have drugs to enhance your blood..

View: https://m.youtube.com/shorts/ZesgGXg19lA

View: https://m.youtube.com/watch?v=mhHvbgNHTqA&pp=ygUYTkZMIHBsYXllcnMgdXNpbmcgb3h5Z2Vu

 

[Sciatic]

What good would it do? The absorption through your lungs is a natural limiter..would be sort of cool to see riders wearing a canula or facemask.. Oxygen tank, maybe a....

View: https://m.youtube.com/watch?v=qnGTCgHGruM&pp=ygUYbWluaSBveHlnZW4gY29uY2VudHJhdG9y


Amgen and a few others already have drugs to enhance your blood..

View: https://m.youtube.com/shorts/ZesgGXg19lA

View: https://m.youtube.com/watch?v=mhHvbgNHTqA&pp=ygUYTkZMIHBsYXllcnMgdXNpbmcgb3h5Z2Vu

you kinda lost me with all those. I wouldn't know if it works or not, might comment is about what's allowable.

 

[memyselfandI]

New findings in sad case of Sivert Bakken:

Avdøde Sivert Guttorm Bakken ble funnet med høydemaske

Skiskytter Sivert Guttorm Bakken hadde på seg høydemaske da han ble funnet død lille julaften. Det melder Norges Skiskytterforbund i en pressemelding.

www.nrk.no

 

[Rob5091]

New findings in sad case of Sivert Bakken:

Avdøde Sivert Guttorm Bakken ble funnet med høydemaske

Skiskytter Sivert Guttorm Bakken hadde på seg høydemaske da han ble funnet død lille julaften. Det melder Norges Skiskytterforbund i en pressemelding.

www.nrk.no

I hope he wasn't playing around with CO inhalation.

 

[Rob5091]

HIF detection possible - from 2024
https://www.sciencedirect.com/science/article/pii/S2667118223000491

Small-molecule HIF stabilizers are being misused in sports to ‘artificially’ increase red blood cells. WADA banned their use, but the structural variety in this relatively new class of performance enhancing drugs and the rapid pace at which new drug candidates are emerging hampers their detection in biological fluids, as many currently used techniques target specific structures – a problem also encountered with NPS. Therefore, a future-proof strategy was envisaged, capable of detecting ANY HIF stabilizer (known AND unknown ones).

Results
The HIF1 bioassay proved to be universal, detecting every HIF stabilizer tested so far (including enarodustat, IOX2, JNJ-42041935, etc.). Using roxadustat as a prototype compound, sensitivity in known urine matrices was determined and ranged from 1-25 ng/mL. A limit-of-detection in blind-coded roxadustat-spiked urine matrices was determined to evaluate routine applicability of this activity-based detection method.

 

[Rob5091]

Red light therapy and boosting mitochondria - a good recovery aid?
https://biologyinsights.com/how-red-light-therapy-works-on-mitochondria/

Specific wavelengths of red (600-700 nm) and near-infrared (700-900 nm) light penetrate the skin to reach underlying cells and tissues. Unlike ultraviolet light, these wavelengths are gentle and do not cause cellular damage.

The primary mechanism of interaction involves a specific enzyme within the mitochondrial respiratory chain known as cytochrome c oxidase (CCO). CCO acts as a photoreceptor, absorbing these specific light photons. This absorption initiates a cascade of biological responses within the cell. The heme and copper centers within CCO are the main sites where this light absorption occurs. When cytochrome c oxidase absorbs red and near-infrared light photons, it stimulates the mitochondrial respiratory chain to operate with greater efficiency. This enhanced activity directly leads to increased production of adenosine triphosphate (ATP). More ATP means cells have more available energy to perform their various functions effectively.