The Olympics were kind of a big deal in amateur cycling before they were open to pros anyway, especially the epic 4-man 100km TTTs which were of significant importance to the different Warsaw Pact nations. We must remember that cycling has two parallel histories for a few decades.
Anyway, while it's my favourite monument in many ways, one of the reasons the Giro di Lombardia suffers a bit prestige-wise is that its route fluctuates much more than the others; while a lot of the key spots - Colma di Sormano, Madonna del Ghisallo - are must-haves, the route changes in the Foglie Morte are much more significant than those in the other four; with more or less fixed start/finish towns, MSR, P-R and LBL can only tinker with the route to a much smaller extent, while the close proximity of many of its climbs makes the RvV route much harder to radically alter in character, even if the particular climbs that make the difference change when the course is altered.
Based on history, MSR is a much more prestigious race than its present incarnation really merits. As a modern race it's by far my least favourite of the five. Echoes always used Zabel's first win as the cut-off, and railed against it being called a sprinters' classic (as opposed to, say, Paris-Tours), because historically it hasn't been. However, in the last 20 years or so, it's regularly been fought out by sprinters or with the sprinters being only narrowly foiled (eg Pozzato's win), though its sheer length and position in the calendar gives it a certain je ne sais quoi that makes it feel rather more than many other races.
That said, I think Roubaix is the only one that absolutely is not able to be replicated. More or less any really long flat race with a couple of bumps near the end can resemble MSR racing-wise (we sometimes see such stages in Tirreno as a preparation, or indeed in the Giro); RvV has some close brethren that use the same Vlaamse Ardennen climbs spread through the season, from Omloop to E3 to Dwars door Vlaanderen and so on; now that the Kapelmuur isn't used in de Ronde we see it creeping into other races too, so that now only really the Koppenberg is sacred. The quest for ever steeper Muritos has left the Ardennes being relatively tame so that LBL has in recent years been arguably the weakest monument, racing-wise, but also as it comes as the focal point of a week of races in similar profiles. Lombardia's less fixed route often means you can see the same kind of racing from a variety of medium mountain Giro stages or other Italian classics with fairly significant hills (Tre Valli Varesine springs to mind), plus of course the actual race itself can be different year on year; the Como-Bergamo route Dan Martin won was a dire race, while the most recent route won by Nibali was an awesome win and the best in nearly a decade. Even though we occasionally see the Tour or the Quatre Jours do the flat cobbles, none of them have quite recaptured the unique feel of Roubaix yet. The Worlds and the Olympics, because the course differs each time, will always be hard to rate, because unlike the monuments, they can't be judged directly against one another. In theory, Cipo's Zolder win and Cuddles' Mendrisio win are equal, and both came with the same title, the same reward, the same jersey. But the two races have next to nothing to do with one another besides the name "World Championships".
That said, while I may eulogise the uniqueness of Roubaix, easily the greatest monument win in my personal memory banks was at Lombardia, and it was Paolo Bettini in Como in the rainbow stripes in 2006.
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