I just ran across this interesting study.
The effect of pedaling rate on coordination in cycling.. It is commonly believed that higher cadences reduce muscle fatigue because they reduce force on the pedal for the same power. But, here is a study that looks at muscle activation for the same power (250W) in competitive cyclists at different cadences. Low and behold, in general, the highest activations occurred at the highest cadences (when the pedal forces would be the least) with the minimum activations occurring in the 75-90 cadence range (check out table 3). Some muscle activations were quite high in the "pushing muscles" at the very low cadence but not a lot higher than seen at the highest cadences. If you believe pedaling (making the pedals go around), per se, doesn't require any energy, how do you explain this finding?
Here are a couple of images from that paper.