Team Ineos (Formerly the Sky thread)

[Tinman]

Sounds eerily similar to USP and Amgen in the early EPO days.

 

[mastersracer]

The diabetes studies of the analogue SRT2104 that look at metabolism and insulin sensitivity will be particularly interesting.

http://clinicaltrials.gov/ct2/results?term=Srt2104&Search=Search

will be great for obese professional cyclists looking to get their cholesterol under control. Besides, these are all tagged now.

 

[Dear Wiggo]

This looks interesting...

http://pharmalicensing.com/public/o...-of-erythropoietin-levels-in-anaemic-patients

Development of an Oral Drug for Stimulation of Erythropoietin Levels in Anaemic Patients


Research
UCSD investigators have designed artificial transcription factors that can activate specifically the endogenous gene for EPO in a patient's own cells. These factors, administered to those prone to anaemia such as cancer patients, have the potential to combat anaemia more effectively than Epogen® or Procrit®.

Compared to injecting manufactured recombinant EPO into the bloodstream of patients, this invention would allow the patient's natural EPO to be produced. It has the potential to be safer, less likely to trigger an immune response, less toxic, more convenient and less painful than injection. The technology also has the potential to up-regulate many other gene targets, not just EPO.

Conclusion
We have designed an oral drug for the stimulation of erythropoietin levels in anaemic patients.

http://pharmalicensing.com/public/pages/contact_us

All the contact numbers are +44 - yeah the UK.

 

[JMBeaushrimp]

This looks interesting...



http://pharmalicensing.com/public/pages/contact_us

All the contact numbers are +44 - yeah the UK.

JV was asked a bit about this on twitter today. He didn't know much about it, but was convinced it would be very easy to test for.

 

[Dear Wiggo]

JV was asked a bit about this on twitter today. He didn't know much about it, but was convinced it would be very easy to test for.

JV in 2009 did not know how the BP worked. He does not know / understand how the test carried out on the U23 rider was useful in determining "cleanness". He does not understand how to calculate watts saved using a skinsuit into calories saved for a race where he has all the data.

I'll wait till @veloclinic or someone with an actual clue pipes up...

 

[JMBeaushrimp]

JV in 2009 did not know how the BP worked. He does not know / understand how the test carried out on the U23 rider was useful in determining "cleanness". He does not understand how to calculate watts saved using a skinsuit into calories saved for a race where he has all the data.

I'll wait till @veloclinic or someone with an actual clue pipes up...

Fair 'nuf. I'd definitely listen to the Capn...

I think the point is any ped that's ingested orally, rather than injected, is more likely to contain elements that are easier to test for via urinalysis. I think. I'm not a doctor, but have been known to play one on the internet...

 

[Tinman]

My hunch is that Sky is doing something around energy metabolism. The weight/diet story, as well as new SIR1 gene stimulants story (eg resveratrol analogues) fit the bill. Aicar also a possible candidate.

 

[Tinman]

... having their doms making some other world class riders look ordinary is too much.

They are missing the experienced Yates in the team car telling the doms to slow down.

 

[Dear Wiggo]

My hunch is that Sky is doing something around energy metabolism. The weight/diet story, as well as new SIR1 gene stimulants story (eg resveratrol analogues) fit the bill. Aicar also a possible candidate.

Watching Brad ride 100rpm up any steepness of hill certainly supports this theory.

 

[thehog]

JV in 2009 did not know how the BP worked. He does not know / understand how the test carried out on the U23 rider was useful in determining "cleanness". He does not understand how to calculate watts saved using a skinsuit into calories saved for a race where he has all the data.

I'll wait till @veloclinic or someone with an actual clue pipes up...

JV said there was more doping 2009 than previous years. Even though everyone said there wasn't.

In print.

 

[Merckx index]

This looks interesting...



http://pharmalicensing.com/public/pages/contact_us

All the contact numbers are +44 - yeah the UK.

From a performance point of view, this is the next best thing to gene doping. While gene doping allows you to raise levels of some natural substance by increasing the number of gene copies encoding that substance, artificial transcription factors allow you to increase the amount of substance synthesized by your normal level of genes.

This will be vulnerable to a passport approach, though. If you raise natural levels of EPO, you will alter the reticulocyte/HT ratio that is the key to the BP. It would also be possible to determine a baseline level of natural EPO, which this approach of course also alters. Where this approach would be highly effective for dopers, though, is in replacing microdosing, e.g., in raising reticulocytes to mask a blood transfusion. Microdosing done properly does not alter the BP parameters enough to trigger a red flag, but it involves a large enough dose of synthetic EPO to be detected in some of the newer tests (discussed here on another thread). This approach would foil that test. That being the case, it would be necessary to develop tests for these transcription factors.

Without knowing more about what this TF is, I would worry about its specificity, i.e., does it activate only the EPO gene, or others as well? But assuming it is highly specific, it should be easily identified by MS or some similar technology. What a doper would really like is a TF with a very short half-life, just long enough to stimulate synthesis of EPO, which hangs around long after the TF is metabolized.

 

[Dear Wiggo]

This will be vulnerable to a passport approach, though. If you raise natural levels of EPO, you will alter the reticulocyte/HT ratio that is the key to the BP.

I realise the BP should help detect changes, but given it's based on a Bayesian model, anyone new (new generation cyclists, they are called) coming in to the BP using this stuff gets to use it with impunity. And given we have no examples of longitudinal (5 years!) range / sensitivity examples we have no way of knowing how strict they are on these ranges, their calculation and year to year allowances. ie older generation cyclists may be able to slowly ramp up usage by manipulating their parameters within range and slowly, over 12-24 months, increasing their limits. Especially possible for teams that have the technology for internal testing.

We just don't know, but there are clues that it's possible.

We do have an example of LA's clearly dodgy profile not even being scrutinised for what ever reason, so it's the BP (in its current state at least) + the panel selection criteria for dodgy profiles that provide 2 weak links in the process for catching doping.

Without knowing more about what this TF is, I would worry about its specificity, i.e., does it activate only the EPO gene, or others as well?n But assuming it is highly specific, it should be easily identified by MS or some similar technology.

Yeah about that....

The technology also has the potential to up-regulate many other gene targets, not just EPO.

 

[pepcalais]

A wise man once said
"The sky is the limit"
But in today’s pro cycling world it should read
"Team sky has no limit"
Drugged out like 2 bit crack *****s.How dare they try sell this farcical
show to race fans.Team domestics still putting the hurt and dropping the
best climbers in the world in the final kms of a MT finish. other teams couldn’t
even have their gun climbers just hold the wheel. Split a team up send some
to P-N and some to T-T and destroy every other team fully committed to one race only. Great "in house training program" guys. Wake up no-one believes it.
Team - SKY
- ALIEN
- ASTRANOMICAL
- EXTRA TERESTRIAL
- COSMIC
- ATMOSPHERIC
_ DISHONEST HABITUAL DRUG ADDICTS
ps. Let’s see em at Chieti in T_T wipe out everyone.

 

[Franklin]

Everyone here thinks Froome has found another gear. Reality is that other riders have lost one.

Every other rider, from every other team lost a gear. And only Sky's riders did not loose it. You bluntly claim that Sky has the onluy 16 clean riders in the world

Hey... nobody would think that's extremely strange considering the antics of the Staff. Sky.. it's angelic.

Master, you simply know that this is a big issue as you skipped this question a few times now. It must be a tadf painful to deep down know that that's REALLY against all odds.

But carry on. Dopers don't fade and only Sky manages to profit from the new clean Peloton. The scouting talent of Dave is beyond amazing, that's for sure.

 

[frenchfry]

Impressive that he probably joined Sky proper in December and in 3 months her has become Contador!

Didn't realise marginal gains can be applied so quickly.

Apparently it's not about "marginal gains" anymore - it's all about "intelligent racing".

 

[Tinman]

This looks interesting...

HIF-1 is a transcription factor that controls Epo production. Several drugs acting on this now in advanced clinical development.

http://www.fibrogen.com/Anemia_Clinical_Studies

 

[Arnout]

Like I said some pages ago, rumors are already that Sky is using something like this. And. contrary to what Vaughters says, it is not detectable and due to the nature of the product might not be detectable ever.

 

[airstream]

Like I said some pages ago, rumors are already that Sky is using something like this. And. contrary to what Vaughters says, it is not detectable and due to the nature of the product might not be detectable ever.

Are Sky geniuses or alchemists? If a key had been so elementary, entire peloton would have used this thing.

 

[Arnout]

Still in early trial, access is key.

 

[Califootman]

So I'm all ready to drink the Koolaid. The mantra of Team Sky's "420W express" is that by riding such a demanding tempo, no one is able to make an attack stick. They can eke out 10 bike lengths or so, but can't maintain the acceleration and then they are left to dangle out in front of the express until they are eventually clawed back. And over the past few days I have seen it work time and time and time again. Brilliant!

But one team knows how to stop the express in it's tracks. One team knows how to make an attack stick, to accelerate and continue to pull away from the group behind. Fortunately for Team Sky, that team is... Team Sky, as shown by the stage-winning attacks in both P-N and T-A where the respective Sky captains launched withering attacks that no one could match, and continued to open ground on the pack remnants until the finish line.

It's like they're Superman while at the same time being Kryptonite to the rest of the peloton! Whoa... I think I need some stiffer Koolaid.

 

[peloton]

That pretty much sums up my feelings.

I was giving Sky some benefit of a doubt and I actually think Porte is one of their more talented riders. But they are ripping it up in 2 different races and having their doms making some other world class riders look ordinary is too much.

This.
+1000

 

[thirteen]

Who knows? Has Wiggins commented in the last 24 hours on Vino? Otherwise, you know, his opinions could have changed. He might never have raced with Vino, or he may have known Vino was doping from 2002, or he may have considered Vino a great warrior and GT winner that he was honoured to race alongside. How would you ever know?

couldn't let that one pass without a chapeau!

i haven't spit coffee across my keyboard in a long time

 

[MartinGT]

Just watching TA and watched PN yesterday.

This is just laughable. Sky with almost a full quota of riders coming to the last climb and looking fresh.

Just laughable.

 

[Dazed and Confused]

Just watching TA and watched PN yesterday.

This is just laughable. Sky with almost a full quota of riders coming to the last climb and looking fresh.

Just laughable.

Luckily Sky's classic team decided to go training on Teide, otherwise they would have annihilated Ronde van Drenthe yesterday as well.

 

[Cycle Chic]

Money from UK, Austrtalia and South Africa

Just watching TA and watched PN yesterday.

This is just laughable. Sky with almost a full quota of riders coming to the last climb and looking fresh.

Just laughable.

Its not laughable to your 'average joe sunday cyclist'.

Its an Australian win from Porte - which boosts viewing figures by millions.

Its a South African / British win - again boosting viewing figures.

These wins attract new viewers - Wiggins supporters !! and anything anglocised.

CYCLING profits either way - and other teams know / understand this. They will profit in the long run by increased sponsorship and salaries. The aim, I believe, is to gain money from UK, Australia and South Africa.