The course is quite technical and the climb pretty tough (just look at the average speeds). That will suit the GC-guys very well - e.g. GT, Dumoulin, Porte, AC, and perhaps LLS (if he's back in great shape after the crash). Also, strong time by Herrada.
Hope he will hurt everyone on the cobbles again. Last year he got a real big mental blow apparently. Lost the pleasure in cycling.
Hope he can deal with the pressure better this year.