The long process of winning back the lost time of stage 4 began the very next day, as more strangeness took place; race leader Óscar Quiroz blew up early and ended up losing several minutes on the main bunch, passing the race lead over to Cristián Rico who finished in a reduced group which included many of the pre-race favourites.
However, that group was itself almost eight minutes behind the day's winner, as 2019 Vuelta winner Fabio Duarte beat Hernán Aguirre and Rafael Pineda on a shootout on the final cat.2 climb as the original breakaway splintered into several pieces. Interestingly, the best of the rest was 21-year-old Edinson Callejas. A lot of teams were absolutely decimated by the pace the last couple of days, with surprisingly enough Orgullo Paísa the worst affected, losing no fewer than four of their riders on this one stage.
Stage 6, on the other hand, had a flat run-in after lengthy descent and a couple of smaller climbs, and saw the CTA team simply manage things for Cristián Rico in the leader's jersey - no use wasting energy when it isn't required, so they looked to limit losses to big guns and held the closest threats close. A 10-man escape then settled the stage, splitting itself in half along the way, and it was one hell of a strong day for Guatemala, as not one but two Guatemaltecan riders made the front quintet. In the end, 20-year-old Boyacense Juan Sossa took the stage win, outsprinting José David Castanuj, the faster of the two extranjeros. Álex Gil started his battle to get back into contention by being 3rd on the day, just ahead of Álex Julajuj who now moves in to the top 10 on GC, and Javi Jamaica. Well known names in the second group on the road included Darwin Atapuma and Óscar Sevilla, who gained around 45 seconds on the remainder of the GC mix in the process.