The new "protection protocols" have coddled the game - especially for the QBs. Love taps where the QB benevolently falls down are being called as "roughing" Lol. As I said before, they might as well just put flags on the QBs & play flag football with them out there.
The gridiron is a battlefield & there will be casualties. And the injuries - including concussions - are occupational hazards. No one is forcing these guys to play football. Many of them forego their senior season in college to declare for the draft & eagerly start playing making the big bucks. And the signing bonuses for the top picks is ridiculous - millions $$$ for never having to step one foot on the field. Lol. And I'm supposed to feel sorry or have concern for these guys if they get hurt or get their bell rung now & then?
As for PEDs & substance abuse - you know it runs rampant in the NFL. How do you think some of these guys have gotten so massive & fast? And PED use seems to be tolerated & accepted by the fans - Hopkins was embraced & 
not booed when he returned to field after his 6 game PED suspension. This is a big contrast compared to other sports like cycling where if a rider is convicted of a doping offense serving a ban, he's roasted by the cycling community & not welcomed back with open arms. Lol
And the league is not using opioid-based pain meds for the most part - the medication of choice is 
Toradol (ketorolac), which is a potent NSAID (for example, Tebow's injured throwing shoulder was injected pregame with Toradol during his entire senior season at Florida).
And back to concussions, Favre estimates he sustained "thousands" during his 20 yr career. IDK about that - he sure looks damn good & seems fine for a 53 yr old in those Copper Fit commercials with Jerry Rice.