I dont know abuot P-R if Pog wanted I would maybe take him over I dont know though I have to admit (and im a big MVDP fan) but the engine of Pog and even though as impressive and good MVDP is in that race (you could argue of the best in recent history even) I still would take Pog over him if he had it as a goal while admiting I dont know.
I think the hardest part for Pog to win is gonne be Sanremo and mainly duo the the downhill section and ofc the part that Poggio has no gradients and very easy to stay on wheel relative speaking. But the downhill if you get a seperation of 5sec you gonne have to lay the season on the line in order to stay ahead and even then it might not be enough for him vs MVDP on a downhill like that.
I think both seem pretty unlikely actually. Probably stupid to bet against him at this point, but if you gave me the over/under on pog winning either (never mind both) I would probably opt against it (and look really stupid)
PR is such a specialized PR, I only see it happen in years time, when Pog's bored of the Tours and just gives it one go for the sake of it. By then, Mvpd might be over the top, and who knows. But I cant see him do it unless he bulks up quite a bit.
With MSR, I don't see him riding everyone off his wheel. It seems impossible. However, if he tries for the next 7 years, who knows, one year they might crash, or puncture, or get group 2 syndrome or whatever behind him. But Sagan was a lab-built San Remo winner, and even he could not get even one after close to a decade as the out and out favourite.