Yes, I have a G3 and manually dialed the Newton+ in over a few rides. If you can borrow a DFPM and do that it helps considerably I have to admit. It takes a little knowledge to be able to look at sections of a ride to see what needs taking and giving to get the results you want. Issac has a DFPM analyzer but I got better results manually studying the data and tweaking. Like building a wheel it needs a human's touch. But after those tweakings I haven't touched it. I only check it occasionally because I'm coming from a Gen3 iAero which I had to tilt and check all the time. The Newton has proved much more reliable as I haven't touched it other than the wind scaling.
To be honest, the Newton with the newer OS is way easier to deal with than a gen3, it's just better everywhere. I never had the Gen3 Iaero give NP scores like the compared DFPM even though the avg. watts were some-what close. I like to use NP as a true guide when riding especially in groups. This really lets you see how it's dealing with all the minor and major accelerations, the newton is really accurate here. The Gen3, not so much in this area, even though avg. watts can be really close(50% of the time). But also remember the DFPM's takes avg. power per crank revolutions while I believe the Newton is picking up an immediate acceleration. So I would think this will cause a slight change or raise the NP while sprinting out of corners or accelerating from a coasting situations(crits and descents). I'm sure someone from Velocomp could let us know for sure, but DFPM's aren't perfect either and it's quite possible this could be an area where the Newton is more precise.
I looked through the file and I would say the winding 7.75 mile descent, avg. 5.2% that lasted 12'50" has the biggest discrepancy at 9 avg. watts.(NP13) for the newton, it read high. Just to let you know how we descended that pass, If I were to download it to Strava I would be about 6 seconds off from the KOM. Over 550 people have descended Glendora Mountain Rd. So we were pedaling hard and sprinting out of the corners. If we soft pedaled down and coasted, the numbers would be insignificant. But, yes, if there were an area where it could use work.....I'm just not sure if it will mean anything.
I don't do a lot of intervals going down mountains so it wont really affect training. But all the combined descents(major and minor) though-out the day is probably what adds the most to the overall wattage difference between the two(newton/DFPM) over the entire ride. I'm not going to try and fix this due to the fact, it's spot on with ascents, rollers, groups, and windy conditions. I'll give that one to the gods and just deduct a couple TSS points at the end of the day when doing group climbing rides, or probably not.