This would definitely be a really tough stage if you had to ride it yourself. 2400 m is the highest point of the Tour and fatigue will set in after more than two weeks of hard racing with many crashes, changing weather and shabby hotel rooms.
On the other hand the final 45 km only contains one climb, so it's doubtful whether the GC riders will dare to attack before that. Pogacar doesn't need it, and Carapaz and Vineyard have already found out that attacking before a long descent isn't particularly rewarding. I expect 20-30 riders to stay together until the final climb. Then it will break down into little groups, a bit like on the Mont Ventoux. Wednesday and Thursday will provide better opportunities for a decisive GC attack.
For the stage win I would expect some of the usual guys in the break. Van Aert needs to start attacking if he wants to win both green and polka dots. Nibali, Valverde, Fuglsang, Chaves, Quintana, Lopez, D. Martin, Buchmann, Rolland and Gaudu all need to salvage their Tour with a stage win, but there are only four mountain stages left. Let's hope that, like yesterday, fortune will favour the brave.