Let's be real. Nibali is at the stage in his career where I'd start getting hyped about smaller wins as well. Don't have Nibali as a Liege winner vs the likes of Alaphilippe, not at this stage in his career, but if he can get 2 good GTs with aggressive riding in and hopefully a stage win that'd be nice.I don't think even his biggest fans were giving him a serious chance in the Giro after last season, but it would still be A chance, and that gives some hope (as well as memes).
As mentioned by another poster, missing LBL is probably a bigger deal, if he does indeed miss it, because it was more realistic that the shark could contend (and it is missing from his palmares).
But to put it all in context (in terms of career importance), this might only be 5% frustration levels for fans compared to Contador crashing in stage 10 of the 2014 Tour.