Back in the 2000s (early-mid) there was a rare edition in which the peloton basically gifted the race to a small break in the first stage, they got a huge gap.
The break was composed of one of the García-Quesada brothers, late Serge Baguet, Oliver Zaugg and two / three more riders.
That was in 2006 and both García Quesada brothers were in the break. In 2005 a similar thing happened, when Carlos García Quesada was leading the race after two stages. At the third stage a large break (about 30 riders) got clear and had a 30 minute advantage on what remained of the peloton in the end. García Quesada lost his red jersey to his teammate Francisco Cabello.