Endogenous vs Exogenous
ImmaculateKadence said:
I'm confused about something here. Some articles say he tested positive for endogenous DHEA, while others specify exogenous. DHEA is produced in your adrenal glands, and a low calorie diet with a lot of exercise can increase DHEA levels. It's even found in your urine. Wouldn't it then be plausible for a cyclist on a calorie restricted diet to test positive for elevated endogenous DHEA? If it were exogenous, then he is guilty. Which one is it? Could somebody with more knowledge explain this?
ImmaculateKadence,
I take it that the implication from Zirbel's positive result is that DHEA was externally administered, through cremes or ingestion and so on. Which is why I wrote "exogenous", or coming from an agent outside the body.
http://bit.ly/91EkxN
What USADA's criteria is for establishing the cutoff for internal vs external is not known to me but I believe they base it off the fact that men, especially at 30 years and beyond, have only so much DHEA within their bodies (which declines with age) and the fact that it also converts to secondary hormones through known pathways.
The
Cycling News article on Zirbel's announcement wrote he tested positive for an "endogenous steroid" which, although may confuse the reader, just seeks to say that DHEA is normally produced in the human body and that Zirbel was found to have an anomalous amount of it in a lab analysis. The lab could also be wrong...