Been there a few years ago. The hairpins on the swiss side are cool, but I acutally found the Italian side even more impressive. There are some extremely narrow hairpins through tunnels further down, which look pretty spectacular. But yeah, I'd love to see that climb in the giro regardless which side.Splügenpass from that side is just stunning.
From the other side you could have Passo San Marco early on, but it would be fa away from the finish line.
The Swiss have been pretty easy with their Covid restrictions because of Tourism, so it could work out.
Otherwise you can always have a really big MTF in Montespluga.
San Bernadino is a badass climb, almost 1,900m of altitude gain.