My take:
Van Aert, van der Poel and Alaphilippe are kind of equally strong. Who wins a race between them depends on form and the characteristics of the race (and tactics of course, but not that much). Van Aert has the biggest engine and produces the best steady watts, van der Poel is probably the best sprinter on a rather flat terrain, and Alaphilippe is the best on a very steep section. Strade suits all of them very well, since they all have a big engine, are technically strong and can deal with the repeated efforts. They are all good in a long, hard race and have a good sprint at the end. Each of their specific strengths can be used in this race. So it will be about form, the most, I think.
One aspect I find interesting here is the form building of van der Poel and van Aert. They seem to have taken a very different approach to the season since they have different goals. Van der Poel carried his cx form into the road season and will, in my opinion, still be great in Strade and MSR. After that his form will probably go down a bit and he will take a rest and build it up again towards the Olympics. Van Aert on the other hand seems to have taken a real rest and already started to build his form for the road properly again, so that he is not yet at his best. I suppose he will be better later in the spring.
So I think van der Poel may have the best form of the three at the moment. But van Aert just has this immense engine, and maybe he's already better than his coach said.
I'd go with van der Poel between the three of them. But then it's not just them at this race. Most interesting for me is actually the "duel" van der Poel-Pogacar. Right now I can't remember a race where they went head to head. Has there been one?
Pogacar could also play a nice tactical card with Formolo - or the other way around. But Strade is really not so much about tactics.
Woods should be in the mix, too. Simmons? Maybe Pidcock, although I'm not on that hype train, yet. And then there's Fuglsang who hasn't shown much so far this season, but it's clearly a race for him, so maybe he will be up there, as well.