Van der Heijden re-test negative for COVID-19, raises doubts over PCR test accuracy
Dutch rider says she will remain in quarantine
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Please feel free to explain to me that this gal is fighting for her survival, her livelihood.
Yes, she has a condition called self adsorbed idiot ars! Because she is not careful, she is more likely to get C19 and spread it, but she doesn't care.It's clear at this point,many at all levels of government have decided that pizza,peet moss or some Stan's no tubes refills are more important than human life. I have said it and others,you can't have a healthy economy unless you have a healthy,and confidence in public safety population.
We can go back and forth about it, nobody will be right because we will have never had the same objectives..so dog chasing his tail kind of thing.
If you are paying attention to American culture and the economy,you see things that replay over and over. An angry person on either side of the Covid public health conundrum..at one end,complete lock down,shop in a store by appointment after deep cleaning and bi daily testing..the other end..couple wearing Kid Rock and a Harley t-shirts, smoking cigarettes and wearing cargo shorts and Crocks saying that Q-Anon has it right and any death is from Anderson Cooper smothering people w w pillow as they sleep or that someone is smearing Corona virus droplets on all the Milwaukee -s best 18 packs at the Grab-n-Go gas station..all normally quote some obscure imaginary law that they know by heart of make reference to a politician that says something compelling about their point of view..
Easy solution, give direction from the federal government.
People will still push the boundaries,but the added level of compliance may improve things,for everyone regardless of which end of the Covid 19 spectrum you fall into.
We have seen what not working together looks like..
Here is a woman in a life or death situation over balloons and party favors,for a kid no less. When you are arguing over the moral weight value of a balloon over human life..you are not dumb but morally bankrupt
View: https://m.youtube.com/watch?v=cmYK8S_OC9Q
Tonight was a dress rehearsal for pushing through a premature emergency use approval for the astra zeneca vaccine. It might work out in the end, but the process is dodgy af.
This type of response to questions about Civic 19 medical data is harming the US and Americans abroad.
EU extends ban on American travelers – again – with US COVID-19 cases far outpacing European countries
For the second time this month, the European Union extended its travel ban on Americans on Thursday, as U.S. COVID-19 infections continued to rise.www.usatoday.com
When Will Americans Be Able to Travel to Europe Again? | Thrifty Traveler
The million-dollar question: when will Americans be able to travel to Europe? Here are some signs of hope that travel to the EU could come soon.thriftytraveler.com
I will be able to get TV coverage and the Cycling news dashboard will have to do!!!Americans: Why You Should Not Bank On U.K., Loopholes, For Europe Travel
The end of the US global travel warning does not mean Europe awaits Americans with open arms. The idea of traveling to EU countries via the UK is unwise and risky. Most members are enforcing the ban, based on your country of residency–and tougher restrictions are on the rise, as is Covid.www.forbes.com
I don't think there is much argument that convalescent plasma (CP) is safe to use. The salient question is whether it is effective and what is the standard of evidence used to determine this point. I've posted positively about CP before, but the recently released evidence that it is doing anything against COVID is not terribly convincing. And AFAIK, the Mayo Clinic study has not even been published in a peer reviewed journal. Somehow, there has been zero randomized control trials completed in the USA. The RECOVERY trial in the UK is struggling to enroll people to finish its randomized trial of CP due to the lack of infections. People on vents generally have good antibody titers. They are not dying from viral burden, but rather from their own immune response attacking the small amount of virus left. Analogously, imagine trying to kill the ants in your house with a blow torch. Which is why dexamethasone is helpful for late stage COVID, but we would never know that in the USA, because we are doing poorly designed science. I see CP as something of a post exposure prophylaxis drug. Definitely, the longer you wait after symptoms, the less benefit you are getting. But, we don't know who is supposed to get CP and in what dosages.Except this wasn't with a fight. What given the emergency approval has been being used since March for large numbers of people and is known to be very safe. The reason given for backing off the emergency approval was because they don't know when it's best used. My problem with that reason is they gave Remdesivir emergency approval without knowing when it's best used, just that it works. Antibody treatment is proven to work and proven safe AND is a treatment that has been used for decades on multiple types of diseases. So it's not even a new treatment. Thus this wasn't worth fighting. Basically don't fight, keep people in place to fight later when it's actually needed.
Also AstraZenica is behind Moderna and Pfizer and last I heard none of them would have early phase 3 results back before Nov. Regeneron's treatment is the one that will have preliminary results back hopefully end of this month and their treatment as a short term preventive maybe by Oct.
I wonder if that is the basis for the 'masks activate your internal coronavirus' people from plandemic? This all sounds like a game of telephone. A person knowledgeable enough to determine nucleotide similarity between human and virus would be knowledgeable enough to know that this string of identical nucleotides has zero implications for the PCR tests. The primers used for PCR are chosen from regions that don't overlap in identity for this very reason. A first year grad student would know this, but it might sound plausible to a random person on facebook. This shows how the information gets degraded as it passes through the human forum. The next step in the process is saying that all the cases are false positives and this proves that the virus is a hoax. This shows the inherent advantage of misinformation. Truth is constrained by facts and evidence, while misinformation is largely not. Ignorance feeds it and there is plenty of that going around.Baltimore, you will appreciate this. It turns out that there is an 18 nt sequence (CTCCCTTTGTTGTGTTGT) in SARS-CoV-2 that is identical to a region in human chromosome 8. I just confirmed that. I don't know how anyone discovered this, but now it's apparently being used as a conspiracy theory, that the SARS-CoV-2 PCR test identifies human genomic DNA. We're all positive, which of course is what the evil people behind this have planned all along.
I looked into that story - they weren't arrested for violating the mask mandate per se - but for trespassing. Apparently the two wanted to go into a grocery store that required masks and the manager locked them out when they became unruly and police were called:Chris I will restate what accomplished and trusted scientists said from the beginning, a healthy economy is based on health,not economy. The dull end of the American spear can't hit the unknown,completely undefined target. To say that schools and school kids can't be protected is completely wrong,soon we will hear arguments that water in bathrooms is a luxury or that school building costs w and without fire alarm and extinguishers should be explored depending on our budget,
should we start the padded dash board,leaded gas,catalytic converter discussion? After all what's the use.?
the federal government stance of step back,this thing will burn itself out,hasn't worked and theoretically can't work. And the other ace in the hole,which is an non ace in the hole is a vaccine. If one is available and is @75% effective,we still have 18-24 months of ramped up immunity time..so 18 months from whatever date is still 18months..so play golf or dominos for a year and a half and revisit the issue then? This is a can that can't be kicked down the road.
View: https://m.youtube.com/watch?v=TFBrDeB_7xw
This is the absorbing public getting the consistent and clear message from the government(s)
This is my country. We don't agree on buying cans of soup or bananas in safety,forget about schools. Schools and elder facility safety is way way way way over the heads of American idiots. This video is last week,this is not March or April.this is public reaction to @175,000 dead fellow citizens..this isn't give me freedom or give me death, this is I want my White Claw and hot pockets and I don't care if it kills you..
This is hyperbole. I don't agree with her defiantly not wearing a mask which I think was socially irresponsible in the current climate but can you explain how the check out woman asking her to leave was fighting for her survival or livelihood ?Please feel free to explain to me that this gal is fighting for her survival, her livelihood.
I don't think there is much argument that convalescent plasma (CP) is safe to use. The salient question is whether it is effective and what is the standard of evidence used to determine this point. I've posted positively about CP before, but the recently released evidence that it is doing anything against COVID is not terribly convincing. And AFAIK, the Mayo Clinic study has not even been published in a peer reviewed journal. Somehow, there has been zero randomized control trials completed in the USA. The RECOVERY trial in the UK is struggling to enroll people to finish its randomized trial of CP due to the lack of infections. People on vents generally have good antibody titers. They are not dying from viral burden, but rather from their own immune response attacking the small amount of virus left. Analogously, imagine trying to kill the ants in your house with a blow torch. Which is why dexamethasone is helpful for late stage COVID, but we would never know that in the USA, because we are doing poorly designed science. I see CP as something of a post exposure prophylaxis drug. Definitely, the longer you wait after symptoms, the less benefit you are getting. But, we don't know who is supposed to get CP and in what dosages.
Lost among the mountain of daily COVID news, last week Fauci and NIH director Francis Collins recommended that CP not be given a EUA, based on the lack of strong evidence of it being effective. They are not part of the FDA decision making hierarchy, but these two might be the most respected scientists in our nation and have access to the best information. Days after this, an angry tweet gets sent by you know who about FDA drug approval. And.... voila... Sunday night, CP gets a EUA. Very dodgy IMO. I get the notion about picking your battles and living to fight another day, but I think knuckling under becomes easier the more you do it.
Which leads us back to the vaccine race. AZ is going to release efficacy data first. Their trial is not big enough to meet FDA standards for approval and are planning on a larger phase III later, so they are not leading in the race for normal approval by the FDA compared to the other ongoing US vaccine efforts. However, timing is everything, and any efficacy from a randomized study from AZ is more evidence than was needed for CP to get a EUA. There will be a EUA for the vaccine by the end of October IMO. Not that anyone will be getting vaccinations at that stage, but that is not really the point of the exercise. The market seems to like AZ since the close on Friday, so there are certainly people who think that where there is smoke there is also fire. It might turn out that it is a really effective and safe vaccine, but the seams are showing in the decision making process and that is concerning to me. Mass resignations hollowing out the FDA in the winter over this is not a great outcome either.
I wonder if that is the basis for the 'masks activate your internal coronavirus' people from plandemic? This all sounds like a game of telephone. A person knowledgeable enough to determine nucleotide similarity between human and virus would be knowledgeable enough to know that this string of identical nucleotides has zero implications for the PCR tests. The primers used for PCR are chosen from regions that don't overlap in identity for this very reason. A first year grad student would know this, but it might sound plausible to a random person on facebook. This shows how the information gets degraded as it passes through the human forum. The next step in the process is saying that all the cases are false positives and this proves that the virus is a hoax. This shows the inherent advantage of misinformation. Truth is constrained by facts and evidence, while misinformation is largely not. Ignorance feeds it and there is plenty of that going around.
But hey...at least here the police aren't enforcing the mask mandates like they are in Australia.
View: https://youtu.be/eBT9fuTJDRE
Remdesivir had a smaller randomized trial to present as data prior to their EUA in addition to the weaker open label study data. CP lacks that standard partly because it has been used so ubiquitously under compassionate use. 35,000 people have gotten it according to reports, but there has been no control group to compare the end points to. You are correct that it doesn't change that much about its use. People were getting it before the EUA and would be getting it without the EUA. The approval decision was mostly for non-science reasons. But it does complicate any future research on CP. How can you run a trial by the institutional review board that randomizes people when the EUA suggests that CP is beneficial? Signing up people may be impossible, so the research designs will yield equivocal answers. The same will be true about any EUA for a vaccine.Why are they holding this to a higher standard than they held Remdesivir? Also from what I can tell this "emergency" approval doesn't change anything for antibody treatment.
I think this is more don't fight this one, when the bigger fight over emergency approval is going to be not doing until ready for vaccines or more experimental drugs.
Pfizer and Moderna have already released their Phase 1 and I think phase 2 trial data. They both started Phase 3 last month. They both are saying they won't have any real data back until Nov. These are large phase 3 trials that will give the data needed. That leads back to Remdesivir didn't have any of this either.
Pfizer and Moderna have released their safety results awhile ago along with results showing that everyone getting the vaccines develop antibodies and are developing T-cells. So I don't see where AZ is even close to where Pfizer and Moderna are.
Edited to add: (I do watch CNBC during the week and this is where this comes from). They were talking about the emergency approval and the talk of one with AZ with a reporter who deals a lot with medical reporting. He said the emergency approval for the plasma isn't really going to change anything at all and even an emergency approval for a vaccine like AZ won't change anything either. People won't have access to it until at best Dec if then. Now he did say the AZ trial in GB was a large trial the problem there is that the numbers of Covid aren't high enough to get full results and that the study in Brazil had a small number.
Remdesivir had a smaller randomized trial to present as data prior to their EUA in addition to the weaker open label study data. CP lacks that standard partly because it has been used so ubiquitously under compassionate use. 35,000 people have gotten it according to reports, but there has been no control group to compare the end points to. You are correct that it doesn't change that much about its use. People were getting it before the EUA and would be getting it without the EUA. The approval decision was mostly for non-science reasons. But it does complicate any future research on CP. How can you run a trial by the institutional review board that randomizes people when the EUA suggests that CP is beneficial? Signing up people may be impossible, so the research designs will yield equivocal answers. The same will be true about any EUA for a vaccine.
The AZ early trial results were published in July. It is a very promising vaccine. The numbers in their efficacy trial would not meet the benchmark to be approved by the FDA. Treatments don't need to enroll as many people because everybody in your treatment group is infected. For vaccines, you need to enroll a whole lot more people because only a fraction of the people will become infected. I doubt many people get any vaccine before 2021. But as I noted, a premature vaccine EUA is not really about the science or delivery of a vaccine.
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)31604-4/fulltext
That tends to keep people from entering the trials at all. Why risk getting placebo?Well they are still doing trials with Remdesivir for both when it's best used and if it's better used in combination or by its self. It's just it can be gotten by people not in trials. (Although it's also cost prohibitive).
As for treatment, I'm still more interested in the results from Regeneron and Eli Lily's lab created antibody tests. Both are currently in phase 3 for using those as both treatment and preventatives.
According to Dr Craig Spencer (he was being interviewed on CNBC) that over 100,000 people have already had it. There haven't actually been any randomized testing for it at all. He's an ER doctor in NYC.
That tends to keep people from entering the trials at all. Why risk getting placebo?
Spencer got CP during the Ebola outbreak, so he would be a good source to talk about it. He is also a pretty interesting guy to listen to in general.