Coronavirus: How dangerous a threat?

Page 215 - Get up to date with the latest news, scores & standings from the Cycling News Community.

Chris Gadsden

BANNED
Oct 28, 2019
131
452
1,230
We found that melatonin usage was associated with a 28% reduced likelihood of a positive laboratory test result for SARS-CoV-2 (odds ratio [OR] = 0.72, 95% CI 0.56–0.91; Fig 8A) after adjusting for age, sex, race, smoking history, and various disease comorbidities (diabetes, hypertension, coronary artery disease, and COPD) using a propensity score (PS) matching method.

Altogether, network-based prediction (Fig 7) and multiple observational analyses (Fig 8A) suggest that melatonin usage offers a potential prevention and treatment strategy for COVID-19; yet, randomized controlled clinical trials are urgently needed to test meaningfully the effect of melatonin for COVID-19.

We found that carvedilol use was significantly associated with a reduced likelihood of a positive laboratory test result for SARS-CoV-2 (OR = 0.74, 95% CI 0.56–0.97) after adjusting for age, sex, race, smoking history, and various disease comorbidities.

Thus, further observations using large-scale independent cohorts to test the meaningful effect of carvedilol in reducing risk of COVID-19 are highly needed.

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000970#sec012
 
The short answer is yes. The long answer is too long and would end up wit ha lot of OT for here.
there probably is no such thing as big picture right now,because it looks like so many variables that making accurate predictions is impossible but..many vaccines coming on line, yes many hospitals are full but technique and technology are making doctors and nurses much more effective in every way from the results they got 3,6,8 months ago. In 3 weeks major changes to many essential systems, but immediate and dramatic will be the Department of Defense. And with some motivating actions at a federal level behavior mods done by law will probably help..masks in all federal agencies and facilities..Army Corp of engineers set to repurpose many things nationwide for testing and treatment..
As we went over 340,000 w December as the deadliest month so far, I hope that some weird planet alignment thing happens and the gun rush to travel doesn't make post Thanksgiving,Christmas,New Year's really devastating.
San Diego hospitals are at capacity..I really hope that all the talk of care rationing is just that,talk and the predictions don't come true.
And Dirt..you better just live with it..I had a guy I really like,smart, hard working,good father,sound business owner tell me w conviction,absolute certainty that Covid numbers were being inflated by fraud because "hospitals get $@60,000 dollars for every Covid patient, so if you fall off a bicycle,horse or ladder they are going to say,Covid to get paid!!" I have w my own ears listened to very similar reasoning from people..often people who I knew to be normal,rational..People to this day,up to the minute buy into the virus being made up, fake, and a worldwide conspiracy to overthrow the US and or Trump. It's not a fringe thing this is real.. Don't be surprised to see tubes of toothpaste in American trash cans and roadways because it's made up, tooth and gum disease is made up by the Chinese..after all have you checked where the brushes are made!! Aaaah..I told ya!
I am scared that too many of these crazy conspiracy theories are about to intersect with disastrous consequences.
in California the hospitals are full and there is still some undercurrent of disbelief. Gavin Newsome has proven himself an idiot again and again for using language,laws and actions that are ambiguous at best. You can't be social distancing at a full airport or shuttle bus. The 2 are different, so the spread of the disease can be seen by satellite or from a car window, full Wal Mart or Target parking lots equal more shutdowns. The genius of Wal Mart and Target is grocery sales..places like Michael 's, Hobby lobby,and Kohl's are open as essential business? Dumb..but not as dumb as Newsome leaving tattoo shops open and closing bars and barber shops.
The virus is spreading,killing 3000+ in a day because that's the way we want it.
And with the 3 Stooges vaccine roll out Don has completely dickt up from the golf course..vaccine is expiring and is not being delivered in promised volumes..atrocious
 
  • Like
Reactions: jmdirt
The holidays here (Belgium) have been really calm. Rules for gathering are strict, and people are quite well motivated to follow them. We've seen cases drop until one of the lowest levels in Europe, and I think that's also stimulating people to hang on. We've seen two huge waves (March and October), and that's enough. It's interesting to see how other countries do. For example, the Czech Republic had a mild first wave, then a huge second wave (October) that has given way to a very high current third wave. That's very tough for hospitals. Switzerland a similar story, only their second wave has never abated and now that they've welcomed thousands of Brits in for skiing, they've very likely also welcomed the variant in with open arms. All that for some ski resort revenue (while all other alpine countries kept their ski slopes closed). There seems to be some kind of 'arrogance' trap that few countries that did well in the first wave have been able to avoid.
 
  • Wow
  • Sad
Reactions: Koronin and jmdirt
Coming from a state in Pennsylvania where there are a lot of restrictions, [NBA] coach Doc Rivers was surprised to see how loose things were in Florida.

“I don’t want to take a shot in any state but, my God,” said Rivers. “Yesterday I was under my bed I was so scared. People are walking around like there’s nothing here, I’m surprised. I know there’s only going to be about 3,000 or so at the arena so that’ll a little safer, but I’ve been pretty surprised how open and maskless this place is.”

 
  • Sad
Reactions: Koronin and jmdirt
The holidays here (Belgium) have been really calm. Rules for gathering are strict, and people are quite well motivated to follow them. We've seen cases drop until one of the lowest levels in Europe, and I think that's also stimulating people to hang on. We've seen two huge waves (March and October), and that's enough. It's interesting to see how other countries do. For example, the Czech Republic had a mild first wave, then a huge second wave (October) that has given way to a very high current third wave. That's very tough for hospitals. Switzerland a similar story, only their second wave has never abated and now that they've welcomed thousands of Brits in for skiing, they've very likely also welcomed the variant in with open arms. All that for some ski resort revenue (while all other alpine countries kept their ski slopes closed). There seems to be some kind of 'arrogance' trap that few countries that did well in the first wave have been able to avoid.

Slovakia quite opposite. Lockdown with lot of exceptions was useless. Lot of people visited his relatives. Before lockdown lot of companies had christmas parties as I know. I know lot of people celebrated new year´s eve in households in big groups or in the mountains. It is bad with 10 000 positives (pcr+ag) 112 deaths and will be worse because hospitals are near collaps. We are sinking and people doesnt care. At least government tighten up lockdown and finally they closed ski resorts. We can go outside but only in our county except for work. But we would need mindset from spring and that doesnt happen. We were scared from Italy. We are Italy now and we are not scared. But I think people will be scared because they will know dead people soon.
 
Yes, I think this all is a very interesting 'experiment' on human psychology. It seems that when countries have "decided" to behave in a certain way (either positive or negative), it is pretty persistent. There seem to be thresholds when people decide to almost collectively throw caution in the wind, or adhere to regulations. Peer pressure not to be the 'odd one out', either in being strict or being loose?
 
Somewhat anecdotal, but, Ireland has gone from one of the best in Europe to the country with the fastest rise in infections. What happened? Shops, pubs and restaurants were allowed to reopen early December.

(The Guardian)
Ireland said on Friday it had under-reported coronavirus cases in recent days by thousands more than previously known as its system came under strain, suggesting the EU’s fastest growing outbreak is worsening even more rapidly than figures showed.
More than 9,000 people who have tested positive for Covid-19 have yet to been added to the official tally of confirmed cases, the National Public Health Emergency Team said. A day earlier it had estimated the number of positive tests still pending registration at just 4,000.
Ireland has gone from having the lowest infection rate in the European Union just two weeks ago to having the fastest rate of deterioration, after shops and large parts of the hospitality sector were allowed to reopen for most of December.
A very large volume of positive tests since Christmas has led to a delay in positive swabs being formally confirmed as new individual cases. Ireland formally reported a daily record 1,754 confirmed cases on Friday, surpassing 1,500 daily cases for the fourth day in a row.
 
Yes, I think this all is a very interesting 'experiment' on human psychology. It seems that when countries have "decided" to behave in a certain way (either positive or negative), it is pretty persistent. There seem to be thresholds when people decide to almost collectively throw caution in the wind, or adhere to regulations. Peer pressure not to be the 'odd one out', either in being strict or being loose?
Herd mentality instead of herd immunity ? Obviously there will be plenty of papers written about pandemic psychology and hopefully some of it will find it's way into pandemic planning for the future. Hopefully politicians are also paying attention, well you can only hope. The next lot of state elections in the USA should be interesting but not only in the USA........there will be years of material for academics to dwell on and write about.
 
They are still doing first come, first served vaccination in this Florida county. What a disaster. Although, if your goal is to get it to the people with the most means, this is probably a good strategy.

View: https://mobile.twitter.com/BrittMullerNews/status/1345360759639969792
the best and brightest, will get the smartest people that there is..it's a promise that was made 4+ years ago..not sure if the organizers are drunk or drinking from the toilet. You may have seen multiple accounts of the United States being described as a third world country..anywhere and everywhere you look, monetary aid, testing, PPE, vaccine distribution and now the utter national chaos to administer the shots..disgraced all of us..and watching other countries..if Trump doesn't feel shame he is brain dead..and the two predominant meds are from the US.. Sputnik zoomed past us..Sinopharm sailed through
 
Larry King, 87, has been hospitalized with COVID. What a tough old buzzard. He's survived multiple heart attacks, lung cancer, stroke, and diabetes. Two of his kids died last year, one from a heart attack, and one from lung cancer. Retired at one point, but has returned to work in recent years.

 
According to a NYT study, on Dec. 5, there were 377,000 excess deaths—deaths above the normal number expected, and thus attributed to C19. That is 31% higher than the officially reported number of deaths on that day by worldometer, about 287,750. If we apply that same % to the currently reported number of deaths of about 358,000, we get a staggering total of 470,000 deaths. I emphasize that these include not only people who died from complications of the virus, but who may have died from other causes indirectly related to the virus—e.g., someone who didn’t seek treatment for a heart condition, because of fears of exposing oneself to the virus at the hospital, or because it was too difficult to get an appointment from the overcrowded staff. Another source would be suicides and drug overdoses, problems that have been exacerbated by lockdowns and other social restrictions. OTOH, some deaths have probably been offset by the fact that social restrictions have reduced the kinds of activities that might lead to death in some instances. But the bottom line is that these are real deaths that, according to statistics, would not have happened but for the pandemic.

https://www.nytimes.com/interactive/2020/us/covid-death-toll-us.html

The NYT analysis is part of an extremely useful link that shows, among other things, the state of every hospital in the U.S. So, e.g., you can check to see how many beds are available in a hospital near where you live. I was drawn to this, because among the pandemic deniers, a common talking point is that total hospitalizations have not actually increased this year, a claim that seems counter to daily reports that C19 hospitalizations are at record highs, and that hospitals all over the country are faced with imminent collapse.

What are the facts? The total number of hospitalizations in the U.S. is at about 65% capacity, a number that has been remarkably constant in recent years. About one-fourth of these, or 17%, are for C19. The worst two states in this respect are CA and AZ, with a little more than 30% of capacity due to C19 patients:


https://www.statista.com/statistics/185904/hospital-occupancy-rate-in-the-us-since-2001/

https://www.beckershospitalreview.c...-hospitalizations-state-by-state-july-15.html

So it’s true that on average, hospitals are not any closer to full capacity than they have been in previous years. But there are a number of qualifications to be made. First, as I noted wrt excess deaths, a lot of people are postponing treatments for other medical problems. This reduces the number of patients. You might ask, if hospitals are only at about 65% capacity, why would they have to do that? That brings up several other points.

First, that 65% figure is only an average. It is much higher in some places than others. In a survey of 2200 counties nationwide, in more than 120, or over 5%, the average hospital was at 90% capacity or higher. Moreover, the situation is even more acute when it comes to ICU beds. In more than 100 hospital service areas, the ICU occupancy is over 100%.

https://www.statista.com/chart/23746/icu-bed-occupancy-rates-in-us-hospital-areas/

Here's a detailed map of the U.S and you can see that many hospitals in the southern part of CA and AZ e.g., are at over 90% capacity, with others scattered across the U.S.:


Second, as mentioned before, the more pressing problem for most hospitals is not space or beds, but staff to care for the patients. Anyone following the pandemic closely is familiar with the stories of burnout of overworked staff, what they’re being asked to do made even worse by the increased risk of infection, which of course further depletes their numbers. The problem is further exacerbated by a lack of up-to-date, reliable data. According to one report about a month and a half ago, almost 20% of all hospitals in the U.S. (more than 1000 out of about 6000) are critically short in staff, and that number surely has grown since.

 
Last edited:
  • Sad
Reactions: jmdirt
According to a NYT study, on Dec. 5, there were 377,000 excess deaths—deaths above the normal number expected, and thus attributed to C19. That is 31% higher than the officially reported number of deaths on that day by worldometer, about 287,750. If we apply that same % to the currently reported number of deaths of about 358,000, we get a staggering total of 470,000 deaths. I emphasize that these include not only people who died from complications of the virus, but who may have died from other causes indirectly related to the virus—e.g., someone who didn’t seek treatment for a heart condition, because of fears of exposing oneself to the virus at the hospital, or because it was too difficult to get an appointment from the overcrowded staff. Another source would be suicides and drug overdoses, problems that have been exacerbated by lockdowns and other social restrictions. OTOH, some deaths have probably been offset by the fact that social restrictions have reduced the kinds of activities that might lead to death in some instances. But the bottom line is that these are real deaths that, according to statistics, would not have happened but for the pandemic.
Like I mentioned a couple of weeks ago, in Belgium, the excess mortality in 2020 was lower than the number of reported covid deaths (15000 vs. 17000). We are reporting very broadly, counting every death that may be attributable to covid, hence our 'high ranking' in covid dead/capita lists (looking at excess mortality, several countries rank ahead of us). Say we are overreporting perhaps a tad, but not much, you'd still have excess mortality underestimating covid deaths, because there has been lower mortality than expected in all age categories < 65 here. I expect that there would be indirect excess mortality in later years because of undiagnosed cancers for instance, but this wouldn't play out immediately. I thus would guess that the real covid mortality in the US may be even more than 470,000 for 2020.
 
  • Like
Reactions: jmdirt

Latest posts