Epo

[Dear Wiggo]

Just because I thought this was humourous... and contemporaneously relevant...

Pediatric Research (1998)

http://www.nature.com/pr/journal/v43/n2/full/pr199834a.html

Human Milk as a Potential Enteral Source of Erythropoietin
<...>
In simulated digestion at physiologic pH levels of 3.2, 5.8, and 7.4, milk-borne Epo resisted degradation at 1 and 2 h, compared with baseline. Therefore, we conclude that human milk contains considerable amounts of Epo which resist degradation after exposure to gastric juices at physiologic pH levels. These results support continued investigation into the fate and developmental roles of Epo in human milk.

 

[Dear Wiggo]

You don't need to inject EPO?

http://www.ncbi.nlm.nih.gov/pubmed/678596

The oral administration of cow milk containing 4 IU human erythropoietin (Ep) to 10-day-old normal neonates for 4 days induced a reticulocytosis. Significant amounts of Ep appeared in the plasma of 1-day-old rats nursed by mothers bled 3 days prior to delivery as compared to nondetectable levels in 1-day-old control rats of normal mothers. The data suggest that Ep is transmitted to neonatal rats via maternal milk, and escapes inactivation, at least to some extent, in the process of absorption from the gastrointestinal tract with consequent stimulation of erythropoiesis in these animals.

Reticulocytosis is a condition where there is an increase in reticulocytes, immature red blood cell

 

[Zultronova]

Just because I thought this was humourous... and contemporaneously relevant...

So drinking cows milk spiked with Erythropoietin, and eating steak contaminated with Clenbuterol, leaves you with the following result.......

 

[Adamastor]

EPO Song

Already posted on this forum, but worthwhile watching again. Appeared on the net during the Tour de France 2007. Funniest song ever written on EPO.

No time to translate lyrics, but if anyone knows French, feel free to do it

http://youtu.be/XaZLlrwvzPQ

 

[Zultronova]

Already posted on this forum, but worthwhile watching again. Appeared on the net during the Tour de France 2007. Funniest song ever written on EPO.

No time to translate lyrics, but if anyone knows French, feel free to do it

http://youtu.be/XaZLlrwvzPQ

Source : http://www.greatsong.net/PAROLES-LA-PLAGE,EPO-TE-QUIERO,102724559.html


Lyrics Epo Te Quiero:


El Don Pedro is your secret to go so fast?


would like you to know I'll tell you.


A DOS TRES


COOL Te quiero
With you I'd be numero Uno
EPO Te quiero
With you I ' have the best jerseys


on the roads of France
I enjoy sunny days
Is not I spend too
If I want to win the round


I ride a bicycle
without effort and without complex


pellotons Far before
I hum a song


Te EPO quiero
With you I'd be numero Uno
La la la la ...
With you I'm faster than tornado


When I have a little bit of pump
A bike
I stopped playing in the edge of a field
Poppy
Then I get out of my gourd
EPO
A good old remedy of yesteryear


And when it comes to the end of stage
I hailed as a hero
Champagne I do not care
I prefer my EPO


EPO Te quiero
With you I'd be numero Uno
La la la la ...
EPO Te quiero
With you I have the best jerseys


in the saddle Attention All
The EPO preneez morning ahead of
a product that the world we want
for you and your bike
It is that EPO you need


Thank you my EPO


EPO Te quiero
With you I'd be numero Uno
La la la la ...
EPO Te quiero
With you I have the best jerseys


Cuter
than Laurent Fignon
EPO
and stronger
than Poulidor
EPO
Much crazy
that Virenque
and more than Bernard Hinault


Thank you my EPO.

 

[Dear Wiggo]

I am curious.

From Tyler's book we know:

1. He starved himself
2. He injected EPO

EPO is injected in the hopes of creating more red blood cells. But RBCs require iron. Without sufficient iron, EPO is wasted.

Starving himself, I would have thought his iron supplies would be low.

Never in his book does he discuss iron tablets, injections, etc in relation to taking EPO to create extra RBCs. It's mentioned once post-transfusion, and once as his first injection with Vit B - before he started actually doping, but EPO is always mentioned as just EPO.

March 30th:
Hamilton's natural Hct was 42.
Hgb: 14.1 g/dL

May 31
Weight: 60.8kg
Hct: 50%
Hgb: 16.4 g/dL


(Very rough calculation follows):

To increase his Hct to 50%, he would need:
Hgb: 2.3 g/dL
Volume of blood: 44dL (Nadler's equation)
Total Hgb mass: 2.3 x 44 = 101g Hgb
Total extra iron: 101g x 3.3mg/g = 333mg of Fe.

So in 2 months, he needs an extra 333mg of elemental iron.

I'll see what he says...

 

[Tinman]

http://en.wikipedia.org/wiki/Human_iron_metabolism

 

[Merckx index]

Already posted on this forum, but worthwhile watching again. Appeared on the net during the Tour de France 2007. Funniest song ever written on EPO.

No time to translate lyrics, but if anyone knows French, feel free to do it

http://youtu.be/XaZLlrwvzPQ

I’d say the second funniest song about EPO. My favorite was the creation of someone over at Podium Café. I’ve modified it a bit. To the tune of Que Sera, Sera:

When I began to race
I asked my DS, how will I do?
Will I win classics? Even GTs?
Here’s what he said to me:

Take CERA, CERA
Whatever you want, you’ll win
The future’s yours to determine
Take CERA, CERA
And you’ll win, you’ll win

Then I became the leader
I said to my teammates, how will we do?
Will we win stages, the whole freaking race?
Here’s what we sang as we paced:

Take CERA, CERA
Whatever you want, you’ll win
The future’s yours to determine
Take CERA, CERA
And you’ll win, you’ll win

Now I have riders of my own
They ask their DS, how will I do?
Will I win classics? Even the Tour?
Here’s what a DS is for:

Take CERA, CERA
Whatever you want, you’ll win
The future’s yours to determine
Take CERA, CERA
And you’ll win, you’ll win

 

[arjanh]

I am curious.
Never in his book does he discuss iron tablets, injections, etc in relation to taking EPO to create extra RBCs. It's mentioned once post-transfusion, and once as his first injection with Vit B - before he started actually doping, but EPO is always mentioned as just EPO.

Maybe he didn't want to write a doper's handbook..

 

[Dear Wiggo]

Maybe he didn't want to write a doper's handbook..

Ah English, you are so subtle in your derogatory tone.

Coz noone else knows how to dope, right?

 

[alvynmcq]

He will have used iron injections pre-EPO to build his iron stores. Maybe he didn't want to get into the boring specifics about iron loading.

 

[Dear Wiggo]

He will have used iron injections pre-EPO to build his iron stores. Maybe he didn't want to get into the boring specifics about iron loading.

Don't need specifics. If you do in fact need iron, it's a gaping hole in the narrative - sure it's helpful to not give all the info re: doping, but also seems....

He describes the EPO as adding "sparkle" to his blood - but EPO's effect takes many hours before retics are created, and they then need to mature into Hgb, so it's very much a placebo effect at first.