Extreme quadriceps starting pain after 3-4 rest days

Page 17 - Get up to date with the latest news, scores & standings from the Cycling News Community.
Jul 9, 2021
2
1
15
Has someone tried to combine cycling with jogging? So for example, you go jogging the one day and the next day you go cycling, then you go jogging again and so on. If yes what were the results? Was there something different, or just pain in the upper and lower legs? And for how long did you do it?
Thanks in advance
I have a lot of experience with this involving running and biking from years spent training for an Ironman.
I could never run first after 2 days off the bike (where my episodes on the bike would usually happen after 3 days of rest). If I did first, within 10-15 minutes of running my quads would slowly get tighter and tighter and that burning sensation would feel like my legs were filling with acid. As soon as it was unbearable I’d stop running and couldn’t restart again no matter what. If I biked first I’d have no issues running. After an episode during running if I biked later that same day and powered through the pain to where it clears up I would be ok to run the next day.
The higher the training load got the less time off was needed to trigger an episode.
 
Finally a diagnosis:

Today I have got the results of my DNA test and a Diagnosis. I have got a defect in a gene in the mitochondrial DNA, which causes, that a step in the cellular respiration may not work as it should. The exact gene is the MTND6 gene and there is one base which got substituted by another, which results in a missense-mutation, thus the protein can work but not as good as it should be.

Ergebnis: Variante m.14349A>G in MTND6 zu 100% detektierbar, den Aminosäureaustausch (p.(Tyr109His)) vorhersagend. (This is the quote from the results, stating what is wrong)

The problem is that this exact mutation has not been documented (or atleast it is stated in my results) in literature yet nor in a database such as MITOMAP, so I guess due to its rarity this will not be helpful for you guys but I just wanted to share it.

If someone wants the full report just message me but it is in German.
 
  • Like
Reactions: Flexx0 and Golden.
Jan 4, 2021
15
1
1,535
Finally a diagnosis:

Today I have got the results of my DNA test and a Diagnosis. I have got a defect in a gene in the mitochondrial DNA, which causes, that a step in the cellular respiration may not work as it should. The exact gene is the MTND6 gene and there is one base which got substituted by another, which results in a missense-mutation, thus the protein can work but not as good as it should be.

Ergebnis: Variante m.14349A>G in MTND6 zu 100% detektierbar, den Aminosäureaustausch (p.(Tyr109His)) vorhersagend. (This is the quote from the results, stating what is wrong)

The problem is that this exact mutation has not been documented (or atleast it is stated in my results) in literature yet nor in a database such as MITOMAP, so I guess due to its rarity this will not be helpful for you guys but I just wanted to share it.

If someone wants the full report just message me but it is in German.

Hey,
Thank you for letting us now!

Are they sure this mutation is causing the issue? Is there anything you can do? Can you keep on cycling?
I'm also German so I'd be interested in the full report for sure!
 
Hey,
Thank you for letting us now!

Are they sure this mutation is causing the issue? Is there anything you can do? Can you keep on cycling?
I'm also German so I'd be interested in the full report for sure!

Due to fact that there are no prior cases they cannot be a 100% sure, but I had CK-Values up to 28.000 and the doctors said, that they could not get that high without some form of gendefect. And this is the only defect gene found, thus I guess it has to be the mutation causing the issue.

I can still cycle and I will continue with it, I have no problem cycling 30-40km but if I do it too hard my muscles will breakdown. If I do not ride 50km a day under a lot of pressure, which means that I have to ride 25km in the morning in 1h and 25km in the afternoon I will be fine. So it is not really restricting me and I can live somewhat without problems, even though I would like to cycle that much.

Currently I do not know if there is a way to treat it but the doctor told me, that a guy from the genetic facility in the hospital is very interested in the case and that I should call him, which I will definitely do.

Hope that answers your questions and I will send you the report in the evening because I am currently not at home.
 
  • Like
Reactions: Golden.
Jan 4, 2021
15
1
1,535
Due to fact that there are no prior cases they cannot be a 100% sure, but I had CK-Values up to 28.000 and the doctors said, that they could not get that high without some form of gendefect. And this is the only defect gene found, thus I guess it has to be the mutation causing the issue.

I can still cycle and I will continue with it, I have no problem cycling 30-40km but if I do it too hard my muscles will breakdown. If I do not ride 50km a day under a lot of pressure, which means that I have to ride 25km in the morning in 1h and 25km in the afternoon I will be fine. So it is not really restricting me and I can live somewhat without problems, even though I would like to cycle that much.

Currently I do not know if there is a way to treat it but the doctor told me, that a guy from the genetic facility in the hospital is very interested in the case and that I should call him, which I will definitely do.

Hope that answers your questions and I will send you the report in the evening because I am currently not at home.

Very interesting! The highest I got Was over 80.000. At that point I wasn't able to bend my legs at all and my urine looked like blood. Don't even get me started on the pain...
I had two one week long hospital checks stays at the Neurological department of the Uni Klinik Jena, but they never bothered doing a genetic panel. I did pretty much every Neurological test available but I refused to do the muscle biopsy, because others with the same symptoms said they got no results from it. Did you ever do a muscle biopsy or was the genetic panel the fist thing your doctors advised?
 
Aug 24, 2022
3
2
15
Hi everyone.

So happy to learn all the stories you had shared. I’m gonna try all advices and analyze each guess. I read all pages in hope to find a certain solution, but it looks like we should wait for some more time for that…

I’m 37 yo man from Russia (peaceful russian…).
172cm high and 78 kg. Before I started to ride road bike I was 95 kg. A ride often for 2 years now.

My first episode appeared last year in the beginning of September after 1,5 week of tempo ride session. I’ve made about 600 km. It was huge for me. Then I spent lazy 2 or 3 days at home and faced the pain somewhere in my hip muscles while I was going down the stares to metro station. I was so scared that I asked my girl to meet me and help to get home. The next day, the pain disappeared. I just forgot about the whole thing for a year.

Now I’m in the end (hopefully) of my second episode. It leasts already for 2 weeks. This season I started to participate in local races so I spent all summer maiking 300km per week. Accidentally I caught a cold and I was forced to stay at home for 3 days, mostly in my bed. After this pause, I got back to my bike and my current episode of pain had started. And it didn’t go away yet. Stretching helps for a short period… rolling hurts a lot.

So all the symptoms are like the most of yours, guys.

In winter, I don’t have this problems - probably, because I train smart, mixing with gym and Nordic skiing. But for the second summer in a row I do only cycling and leave everything else aside, so, I’m having this episodes in August/September.

I will try to implement more different training types in my life. It may be some kind of key.

I was doing CrossFit since 2014 and sometimes I got carried away with it, but I never faced those attacks.

Btw during my current episode I tried to spin through pain (when the pain was less obvious) and I reached success. I think it should be some effort around ftp, not just spin around. It works. But I want to understand the exact mechanism of this shi*…

Wish to solve this problem for all of us. Stay health and peace to all of you.

P.S. Please don’t forget shere your stories here. I read this pages for a week and now when I finished, I don’t now what to read next.

Sorry for my poor English
 
Hi everyone.

So happy to learn all the stories you had shared. I’m gonna try all advices and analyze each guess. I read all pages in hope to find a certain solution, but it looks like we should wait for some more time for that…

I’m 37 yo man from Russia (peaceful russian…).
172cm high and 78 kg. Before I started to ride road bike I was 95 kg. A ride often for 2 years now.

My first episode appeared last year in the beginning of September after 1,5 week of tempo ride session. I’ve made about 600 km. It was huge for me. Then I spent lazy 2 or 3 days at home and faced the pain somewhere in my hip muscles while I was going down the stares to metro station. I was so scared that I asked my girl to meet me and help to get home. The next day, the pain disappeared. I just forgot about the whole thing for a year.

Now I’m in the end (hopefully) of my second episode. It leasts already for 2 weeks. This season I started to participate in local races so I spent all summer maiking 300km per week. Accidentally I caught a cold and I was forced to stay at home for 3 days, mostly in my bed. After this pause, I got back to my bike and my current episode of pain had started. And it didn’t go away yet. Stretching helps for a short period… rolling hurts a lot.

So all the symptoms are like the most of yours, guys.

In winter, I don’t have this problems - probably, because I train smart, mixing with gym and Nordic skiing. But for the second summer in a row I do only cycling and leave everything else aside, so, I’m having this episodes in August/September.

I will try to implement more different training types in my life. It may be some kind of key.

I was doing CrossFit since 2014 and sometimes I got carried away with it, but I never faced those attacks.

Btw during my current episode I tried to spin through pain (when the pain was less obvious) and I reached success. I think it should be some effort around ftp, not just spin around. It works. But I want to understand the exact mechanism of this shi*…

Wish to solve this problem for all of us. Stay health and peace to all of you.

P.S. Please don’t forget shere your stories here. I read this pages for a week and now when I finished, I don’t now what to read next.

Sorry for my poor English
Hey,
did you ever go to the hospital during one of your episodes (you did not mention it so I am curious), because if not I would highly recommend it, otherwise your kidneys could really suffer from this episodes. Even though I have not read a report in here, where someone got any kidney damage I would choose the save way. If not, remember to drink a lot of water to get the CK and other molecules out of your body. (During my episodes I drink 8-10 liters a day, I know this is not very healthy either but it flushes the CK out very efficiently and I test my blood regularly during the episode or I am already in the hospital. Find the way that suites the best for you because I would not recommend drinking that much.)

And to the spinning-through-thing I have experienced the same. If I start to cycle at the beginning of an episode, when I slowly start to feel the pain, it vanishes and goes away. Asked my doctor about it and he told me, that he thinks, that it is the same with muscle ache because there the pain also vanishes when you continue to train.

Get well soon and don't stop the grind :)
 
  • Like
Reactions: lohmatik
Aug 24, 2022
3
2
15
Hey,
did you ever go to the hospital during one of your episodes (you did not mention it so I am curious), because if not I would highly recommend it, otherwise your kidneys could really suffer from this episodes. Even though I have not read a report in here, where someone got any kidney damage I would choose the save way. If not, remember to drink a lot of water to get the CK and other molecules out of your body. (During my episodes I drink 8-10 liters a day, I know this is not very healthy either but it flushes the CK out very efficiently and I test my blood regularly during the episode or I am already in the hospital. Find the way that suites the best for you because I would not recommend drinking that much.)

And to the spinning-through-thing I have experienced the same. If I start to cycle at the beginning of an episode, when I slowly start to feel the pain, it vanishes and goes away. Asked my doctor about it and he told me, that he thinks, that it is the same with muscle ache because there the pain also vanishes when you continue to train.

Get well soon and don't stop the grind :)
Hey, thanks for answer)
Yes this time I checked blood parameters including CK level and it was normal. But my results was in different from yours values. 3,6 ng/ml when <5,2 is reference. May be I checked my blood too late. Not in the beginning of episode. Next time I’ll check right away. I’ll post here)
 
Last edited:
Aug 24, 2022
3
2
15
Guys i've just thought. if we are considering this episode as a chemical metabolic phenomenon why it's getting better when starting stretching? Ok, it is hurt and helps for short period but still. Looks like if it is metabolic you wouldn`t fix it by mechanical.
Just thoughts
 
Last edited:
Hey fellow sufferers,
I have got an update from my case. I recently saw a human geneticist, who my doctor recommended to see, and showed him my genetic report. He looked at the report and my case and registered me as a participant for the MitoNet, they will now look at my DNA or mtDNA or both in more depth and do some more tests with it (I do not know what they are exactly doing, but the geneticist said they will test if my punctual mutation in my mtDNA really is the cause for my symptoms or something else.).

He said the whole procedure will take 1-2 years and then I will finally now the cause.

So for me there will (hopefully) be an answer soon.
 
Dec 31, 2020
20
4
1,585
Hi all..

I just wanted to share that I haven't had any episodes in nearly 2 years. Last time was when I found this forum and also went to the hospital for the first time. I had been suffering them fairly regularly ) at least a few times per year) since 2009. All that I have focused on is limited sugar / carbs and staying hydrated. I was forced off training earlier this year for about 6 weeks and had no issues whatsoever. So for me, the obvious and simplest thing to do is limit binging / overeating carbs and sugar and also drinking plenty of fluids all the time. If nothing else, it definitely helps.
 
Jan 2, 2023
2
0
10
It seems very common to me, since when you exercise the muscle does not hurt that same day, it hurts the following two days.



____
https://hhprocessors.com


This is why I haven't bothered going to the doctors with it as I know it will be dismissed as DOMS. I could cycle every day for a year and feel great every day, but just one day off and I'll be in pain and unable to walk. This isn't cramp from exercise, it is from a day of inactivity.

I did the festive 500 over Christmas, cycling a bit every day and also totalled 12 consecutive days of cycling . New years day was a planned rest day, despite feeling well rested. I get up in the night for a pee and upon returning to bed I get intense cramping in my leg that has returned this morning as I start walking around the house sorting breakfast. Just a few steps will trigger it and the pain will last hours afterwards. Likewise if I jump on a bike and do very light cycling, a normal warm up, my legs will cease up with intense cramp within 2 minutes.

This is something I've been suffering with for 10 years, ever since getting a bike as an adult, I never had a problem as a child. Back then I was only doing the odd day here or there and would then cease all cycling when the problem started and it would take a week or two to stop completely. Now I understand the triggers better, I push through it with more cycling, the best cure seems to be an hour of intense cycling as soon as I feel the start of the cramp starting, enough to feel some actual DOMS and then continue with a normal cycle every day. I could be unable to walk 50m in the morning, do an intense cycle and then be able to walk for miles straight after pain free.
 
Dec 31, 2020
20
4
1,585
This is why I haven't bothered going to the doctors with it as I know it will be dismissed as DOMS. I could cycle every day for a year and feel great every day, but just one day off and I'll be in pain and unable to walk. This isn't cramp from exercise, it is from a day of inactivity.

I did the festive 500 over Christmas, cycling a bit every day and also totalled 12 consecutive days of cycling . New years day was a planned rest day, despite feeling well rested. I get up in the night for a pee and upon returning to bed I get intense cramping in my leg that has returned this morning as I start walking around the house sorting breakfast. Just a few steps will trigger it and the pain will last hours afterwards. Likewise if I jump on a bike and do very light cycling, a normal warm up, my legs will cease up with intense cramp within 2 minutes.

This is something I've been suffering with for 10 years, ever since getting a bike as an adult, I never had a problem as a child. Back then I was only doing the odd day here or there and would then cease all cycling when the problem started and it would take a week or two to stop completely. Now I understand the triggers better, I push through it with more cycling, the best cure seems to be an hour of intense cycling as soon as I feel the start of the cramp starting, enough to feel some actual DOMS and then continue with a normal cycle every day. I could be unable to walk 50m in the morning, do an intense cycle and then be able to walk for miles straight after pain free.

Sorry to hear you've had a recent episode of this. It was 2 years ago as of a couple weeks ago that I had my last major flare up / episode. For me, it was often around holidays when I'd be off the bike a bit more and imbibing in some alcohol and sweets. I can tell you that the BIGGEST thing for me is, when not training every day, to be adequately hydrated and to limit sugar. Doing this has kept me issue free for a long time. For me it was usually triggered with some sort of downhill walking or walking down stairs. Another thing is that I'm sure your CK levels spike during this and can cause damage to the kidneys if not addressed ASAP.

congrats on your festive 500! Was it on Zwift?
 
Jan 2, 2023
2
0
10
Sorry to hear you've had a recent episode of this. It was 2 years ago as of a couple weeks ago that I had my last major flare up / episode. For me, it was often around holidays when I'd be off the bike a bit more and imbibing in some alcohol and sweets. I can tell you that the BIGGEST thing for me is, when not training every day, to be adequately hydrated and to limit sugar. Doing this has kept me issue free for a long time. For me it was usually triggered with some sort of downhill walking or walking down stairs. Another thing is that I'm sure your CK levels spike during this and can cause damage to the kidneys if not addressed ASAP.

congrats on your festive 500! Was it on Zwift?


I'm skiing in 2 weeks time and am very concerned about it. Currently I can't be off the bike for much more then 24 hours without having problems. I'm desperately hoping that if I cycle before leaving for the airport that I can make it through to the slopes the next day and build up enough fatigue skiing to keep the issue at bay.

I don't consume a lot of sugar (but plenty of carbs through bread, pasta, potatoes). I don't drink alcohol at home any more and keep things moderate when drinking out on rare occasions. I drink plenty of liquids and my pee has never been dark.

I've been thinking about getting a private blood test for CK levels after a couple of days of rest and presenting it to the doctor, the only thing stopping me is I'm not sure I can face the pain and fighting through it to get back to normal. Or otherwise just writing a letter to my GP in the hope that they will keep a open mind reading through it. But I don't have the best experience with medical professionals.

Yes, a Zwift Festive 500, so not quite as much volume as the real thing but I stopped cycling in less ideal conditions after a nasty crash a couple of years back.
 
Feb 21, 2023
3
1
10
this is an interesting thread, I have not read every single response in detail but my take away is that there is still no unifying definitive diagnosis.

fyi I am a physician, I do emg/ncv testing, I have corresponded with Katie Compton some years ago, I have 23andme genetic data from chip V3 (960,000 snps and V5 640,000 snps and no hits for a genetic mitochondrial defect to explain these symptoms and I have found no definite unifying answer/diagnosis.

most mitochondrial diseases have no treatment anyway, so it seems likely a futile effort, and mitochondrial disease is very unlikely in a patient who can otherwise reach a very high level of fitness.

I think most likely what is happening is the fact that cycling only loads the muscle in a concentric fashion, and the muscle is adapting to the concentric loading of the cycling motion, at the expense of the muscles ability to tolerate eccentric loading, such as running or walking downhill. this intolerance of eccentric loading is the only unifying pattern I have and seems to hold true for most of the posts I have read in this forum.

now without getting to far into the weeds of muscle physiology, you can review actin/myosin and the mechanism of how they work together for muscle contraction and relaxation at the level of the sarcomere, interestingly an ATP is required to release the myosin head, maybe this is related or not. the lack of ATP to release the myosin head is what causes "rigor mortis".

so lets say there is some discovered genetic defect, how likely is it there will be a treatment to fix it, I think extremely unlikely, so all your left with is supportive measures, different training, etc.

one option is to quit cycling, I did for a couple of years and no symptoms ever. if you want to keep cycling, the most effective strategy I have found is to be sure and give the cycling muscles some eccentric loading, before a rest period. the easiest way to do this is lunges, sometimes just your body weight is sufficient, if not you may need dumbbells of various weight as to increase the amount of eccentric load. with some trial and error you should be able to figure how much lunging or even squats you have to and how often to minimize a flare during or preceding a rest period. it might be daily, every other or every 3. depending on how quickly your symptoms come on, you may have to lunge after your last ride, or maybe you can wait a few days.


I think there is one area of genetics that might give some insight, which is that for alpha-actin-3. from 23andme I am TT, which means I don't make the protein, this protein is more common in elite power athletes, and it is involved in sarcomere structure. So if there happened to be a high correlation for this protein genotype within this forum that would be interesting, but I won't be holding my breath, lol. around 20% of European ancestry has the TT, and it is present in fast twitch fibers. so if you had this genotype, and had a higher percentage of fast twitch fibers you might be more susceptible to the concentric only muscle stress of cycling. but there is a lot of might and maybe in that statement.

here is a link to a good article discussing this protein.
https://www.frontiersin.org/articles/10.3389/fphys.2017.01080/full
 
Last edited:
Jan 4, 2021
15
1
1,535
this is an interesting thread, I have not read every single response in detail but my take away is that there is still no unifying definitive diagnosis.

fyi I am a physician, I do emg/ncv testing, I have corresponded with Katie Compton some years ago, I have 23andme genetic data from chip V3 (960,000 snps and V5 640,000 snps and no hits for a genetic mitochondrial defect to explain these symptoms and I have found no definite unifying answer/diagnosis.

most mitochondrial diseases have no treatment anyway, so it seems likely a futile effort, and mitochondrial disease is very unlikely in a patient who can otherwise reach a very high level of fitness.

I think most likely what is happening is the fact that cycling only loads the muscle in a concentric fashion, and the muscle is adapting to the concentric loading of the cycling motion, at the expense of the muscles ability to tolerate eccentric loading, such as running or walking downhill. this intolerance of eccentric loading is the only unifying pattern I have and seems to hold true for most of the posts I have read in this forum.

now without getting to far into the weeds of muscle physiology, you can review actin/myosin and the mechanism of how they work together for muscle contraction and relaxation at the level of the sarcomere, interestingly an ATP is required to release the myosin head, maybe this is related or not. the lack of ATP to release the myosin head is what causes "rigor mortis".

so lets say there is some discovered genetic defect, how likely is it there will be a treatment to fix it, I think extremely unlikely, so all your left with is supportive measures, different training, etc.

one option is to quit cycling, I did for a couple of years and no symptoms ever. if you want to keep cycling, the most effective strategy I have found is to be sure and give the cycling muscles some eccentric loading, before a rest period. the easiest way to do this is lunges, sometimes just your body weight is sufficient, if not you may need dumbbells of various weight as to increase the amount of eccentric load. with some trial and error you should be able to figure how much lunging or even squats you have to and how often to minimize a flare during or preceding a rest period. it might be daily, every other or every 3. depending on how quickly your symptoms come on, you may have to lunge after your last ride, or maybe you can wait a few days.


I think there is one area of genetics that might give some insight, which is that for alpha-actin-3. from 23andme I am TT, which means I don't make the protein, this protein is more common in elite power athletes, and it is involved in sarcomere structure. So if there happened to be a high correlation for this protein genotype within this forum that would be interesting, but I won't be holding my breath, lol. around 20% of European ancestry has the TT, and it is present in fast twitch fibers. so if you had this genotype, and had a higher percentage of fast twitch fibers you might be more susceptible to the concentric only muscle stress of cycling. but there is a lot of might and maybe in that statement.

here is a link to a good article discussing this protein.
https://www.frontiersin.org/articles/10.3389/fphys.2017.01080/full

But how does triggering an attack by increased carb intake factor into all of this? I agree with the idea that the lack of eccentric muscle contractions are the root cause, but for me carb intake does also play a huge role. I can easily trigger an attack by overdoing it on the carbs (like 2000 kcal+ of sugars) if I don't put in enough work on the bike.
 
Feb 21, 2023
3
1
10
But how does triggering an attack by increased carb intake factor into all of this? I agree with the idea that the lack of eccentric muscle contractions are the root cause, but for me carb intake does also play a huge role. I can easily trigger an attack by overdoing it on the carbs (like 2000 kcal+ of sugars) if I don't put in enough work on the bike.
It probably modifies some inflammatory cytokines, maybe you have undiscovered insulin resistance and the sugar affects how the muscle can use/store glycogen , now if you could prove you are symptom free say on a strict ketogenic diet and proven to be in ketosis by way of blood ketone measurement that would be interesting, and maybe point to a larger role of mitochondrial function
 
Jul 7, 2015
14
2
8,535
Does anyone here have gout? I have had a full genetic workup to try an solve my rhabdo issue, including a biopsy of my quad and an analysis of mitochondrial electron transport. Everything has been negative for known defects.

But, I do have gout and started taking allopurinol a year ago. Concurrently I have not have much rhabdo. Correlation is not causation, but I thought I would share to see if anyone else has a similar story. I also found this .... https://europepmc.org/article/pmc/4255256

I am a white male, mid 40s. Based in NYC.
 
Apr 13, 2023
2
0
10
Hi,
I have had a strange experience this week. I have been following my base training program for about 10 weeks with riding everyday including recovery rides etc.

Then for different reasons I had to take 4 days of from riding over the weekend. Then on Monday 20 minutes into my warm-up, I got extremely sore muscles in my left quadriceps. I had to stop, it was so painful.

Tuesday morning i tried to mount my bike again, but after 5 minutes, I got this extreme pain again and had to stop. Later I visited the chiropractor who thought it was a trapped nerve in the back, but she couldn't find anything, and it had no effect.

Wednesday morning I tried again, but same story. I couldn't even bike to work, which takes 5 minutes. I consulted my doctor who said it was over training, and that I should take 14 days off. I was/am a little skeptical because I have never heard of over training bringing on such severe pain. And I haven't experienced any of the symptoms related to it.

The pain is hard to describe but feel like acid in the legs that burn, and it doesn't go away. Here 24 hours after my short ride to the doctor, my legs are still sore. The pain only comes on when I bike or walk down the stairs, not up.

By accident I found this thread on a danish forum, translated into English here, and the OP basically explains the exact same story. Same symptoms with walking on stairs only biking a few km's etc. it reveals that quite a few people have experienced the same problems, without ever getting a proper diagnose.

Everyone describes how this has started after a few days of rest due to traveling and so on.

Anybody experienced anything like it, or can explain what might cause it. I can not find anything on the english-speaking web.
Your post is really helpful!
 
Apr 27, 2023
1
0
10
Glad to find people with the same symptoms as me. In fact, I found this article around 2014, but there was no meaningful progress at that time. At that time, I didn't pay attention to the post that said to pay attention to glycogen, but today I found out that it was a horse's Monday disease, and I thought it was worth a try. I have a solid solution for this one. my exact symptoms
1. I ride my bike in a competitive environment.
2. When I take a break, sometimes on the 2nd or unconditionally 3rd day, extreme pain comes .
3. If I do not ride a bicycle at all after the pain, the pain disappears after about 5 days and this symptom does not appear.

The solution is to get a prescription for Tramadol and when the pain is almost gone, quickly do strong training on a trainer. If you do this, the symptoms will go away in just a few hours.
Of course, it is best not to rest for more than two days.
 
Aug 13, 2023
4
1
15
I'm glad to find these threads with the same symptoms as me.

I am a 33 years old Korean and it has been about 3 years since I had this symptom. It happened after 3 months of riding the bike for the first time.

I have exactly the same symptoms, and it happens every month.
I have no problem going up the stairs, but when I go down the stairs, I feel extreme pain and heat in my quadriceps, as if stabbing my quad with a knife.

Through the threads written here, I found out that Katie Compton has the same symptoms, and she seems to have confirmed the cause with the MTHFR genetic test. So I'm going to do the same MTHFR test.

In the meantime, I found an episode of a person experiencing the same symptoms on YouTube, and he seems to have identified the cause of this pain as uric acid. So, in addition to the MTHFR gene test, I am also trying to measure the uric acid level. After testing I will share the results in this thread.

Have any of you had your uric acid levels tested?
 
Last edited:
Jul 26, 2021
2
1
1,515
I'm glad to find these threads with the same symptoms as me.

I am a 33 years old Korean and it has been about 3 years since I had this symptom. It happened after 3 months of riding the bike for the first time.

I have exactly the same symptoms, and it happens every month.
I have no problem going up the stairs, but when I go down the stairs, I feel extreme pain and heat in my quadriceps, as if stabbing my quad with a knife.

Through the threads written here, I found out that Katie Compton has the same symptoms, and she seems to have confirmed the cause with the MTHFR genetic test. So I'm going to do the same MTHFR test.

In the meantime, I found an episode of a person experiencing the same symptoms on YouTube, and he seems to have identified the cause of this pain as uric acid. So, in addition to the MTHFR gene test, I am also trying to measure the uric acid level. After testing I will share the results in this thread.

Have any of you had your uric acid levels testedu
 
Jul 26, 2021
2
1
1,515
I had biopsy. The biopsy show my muscles have difficulty absorbing glycogen.
I had genetic testing - this didn't find anything.

High uric acid is the main cause of gout. (A previous reply mentioned they have gout.)
I get gout too. I am taking Allopurinol also but this pain started years before the Allopurinol.

There might be some link.
 
  • Like
Reactions: Daniel Seo
Aug 13, 2023
4
1
15
Hi all
I've had a number of episodes of this issue and have been working with my coach (Phd with focus on sports science and genetics) and some sports doctors, and have come up with a hypothesis as to what is going on:

Onset of the condition in my case:
- relatively high training / racing load
- 3-4 days of inactive rest
- normal / increased carb and sugar intake during the training load, and importantly no moderation /and often an increase in carb and sugar intake immediately during the rest period (ie pigging out a bit post a stage race / big block, or at least not reducing intake during this period)

Manifestation
- pain as described above, in quads, calves, hammies, abductors, glutes.
- importantly the fact that during an episode the pain moves around (anterior, posterior, right leg, left leg) indicates that this is not a nerve/skeletal issue
- significantly increased CK levels indicating some for or myopathy
- CRP levels normal indicating that it isn't an autoimmune issue

Hypothesis
- the issue is an enzyme related issue in the muscles specifically related to the production of glycogen synthase.
- glycogen synthase is the enzyme which is responsible for converting glucose into glycogen for storage in muscle cells.
- in a "normal" person, during high load, levels of glycogen synthase increases in order to store fuel to meet the increased requirement for energy for the body. When exercise load decreases, the body automatically regulates the level of this enzyme as the body's need for stored glycogen reduces.
- the theory that we are working with is that in my case, the body is not regulating this enzyme level, and so the body is continuing to convert glucose into glycogen and packing it into the muscle cells.
- the problem is twofold in that firstly exercise has stopped and so the glycogen is not being used (but continues to be stored) and sugar and carb intake has not reduced (and often increased) so there is excess in the body and it is being stored.
- the theory is that the muscle cells get overloaded with glycogen and when exercise is introduced, the cells literally tear as a result of being overloaded.
- this accounts for the pain felt, as well as the increased CK levels.
- the hypothesis is that this is a genetic issue and there isn't a "cure" as such

Prevention and treatment
- active rest as opposed to inactive rest has been effective in preventing onset (ie. 90 minute low intensity sessions with not more than a day of inactive periods).
- significant reduction of carb and sugar intake as the rest period starts
- during the most recent episode I went into a LCHF (virtually carb free) diet and within 2 days had no more pain
- during the episodes, multiple, short (10-20min) sessions until onset of pain, with aim of stimulating metabolism and effectively burning off glycogen
- once pain had subsided, introduced low intensity IMTG rides for the first few sessions.
- use of ibuprofen to assist with inflammation in Muscles and for pain during the episode
- increase water intake to assist kidneys with CK load

As I said, this is a theory that the guys i am working with have come up with and it seems to make sense and be working for me. I'm sharing it with you simply because I know the frustration and the pain associated. If (and hopefully we don't have another episode given our prevention strategy) we have another episode, we will need to do a muscle biopsy to test the theory - obviously invasive so would prefer to avoid!!

Once again, this is a theory - hopefully it helps!!
 
Aug 13, 2023
4
1
15
I had biopsy. The biopsy show my muscles have difficulty absorbing glycogen.
I had genetic testing - this didn't find anything.

High uric acid is the main cause of gout. (A previous reply mentioned they have gout.)
I get gout too. I am taking Allopurinol also but this pain started years before the Allopurinol.

There might be some link.

I'm not sure why that hypothesis(Drewza101) was buried, but I think it's the hypothesis that most effectively explains the symptoms we have that pain after 3 days rest, especially after high exercise load, only in the quadriceps, slight swelling of the quadriceps before the attack, etc.

Also, I think it has a lot to do with carbo-loading(glycogen loading) that bodybuilders and marathoners do.

I'll check it more about this mechanism and post it in this thread.
 
Last edited:
  • Like
Reactions: OldBoyBiker