based on a single study of Angelillo-Scherrer et al, i am trying to figure out if Gas6 has the potential as a doping agent
let's look at several groups to understand the applicability
1. A healthy, non anemic adult -Hct=45% with some fluctuations due to a life style (elevation, diet etc). When given EPO, easily responds by raising hct above 50%. not the subject of the study.
2. Anemic adult - Hct-30%. May or may not respond to EPO (for ex, 50% of cancer patients don’t respond). not the subject of the study.
3. A healthy professional rider, good EPO responder - Hct=42%. hct easily pushed to over 50%. not the subject of the study.
4. Anemic mouse, non-responsive to EPO alone (a case similar to humans in para. 2). not THE subject of the study.
5. Anemic, epo-alone non-responsive mouse that responds when epo was co-administered with Gas6. the subject of the study.
let's entertain how a healthy professional athlete can become a sick mouse that does not respond to epo alone ?
Simple. from the study: he/she has to:
- make rbc where humans don’t - the spleen.
- possess a pathology that results in anemia (cancer or excessive rbc destruction for whatever cause etc…)
- be an epo doper to begin with
To achieve a purely theoretical possibility of having the mouse study apply to a pro rider we must assume that he would benefit from gas6 ONLY if he was anemic AND a poor epo responder, natural or exogenous, does not matter. Fair enough, no medic would be surprised if a poor epo responder becomes anemic. right ?
but here is the first problem. how would a rider become an elite endurance pro if he is lacking the key precondition of any elite performance - having a healthy rbc reproduction in the first place? Well, the clinic expert might retort, 'he consumed mega doses of epo or transfused own or someone’s blood all along…'
this brings us to the second problem - the precondition for Gas6 effectiveness is presence of epo, which means he doped with both epo and gas6 since being a junior.
this is a catch 22 game. needless to point to the absurdity of such logic. But as a clinic topic it is perfect.