Valverde will easily be able to top-5 in TdF with his old schedule and all the riders (I assume) who are racing Il Giro. The closest to real hard mountain stage is the one to Chevalier and its not overly hard.
However, the biggest goal should be to win another Liege. A 4th Flèche in a row would't be too bad either.

I don't know about De Ronde, he can't win it, so I wouldn't bother too much. With Izagirre out and Quintana maybe racing Il Giro, Pais Vasco should be another season goal. I still can't believe he hasn't won that yet.