I agree this is a must win for the Chargers. In fact, the expectations there have to be they will then go to KC, and give the Chiefs a run for their money. If they get by Houston, then lose handily to the Chiefs, it may as well be 2022 all over again.
The Bills can beat anyone in the NFL. But the two teams that I think can beat them are Baltimore, who has done so a couple times (including
earlier this year, 35-10, where the Bills could not stop Lamar, or Henry), and KC, at least in KC, though they have done it in Buffalo too.
I'm not sure about the Ravens beating KC. I'll believe it when I see it. They almost did in week 1. But last year Harbaugh was easily outcoached by Reid, Lamar didn't play well, and they couldn't stop Mahomes.
The Bills rested a lot of players, but I was impressed by how accurate Joe Milton was!
KC hasn't had anywhere near the loss of players the Lions have. It's not even close. Injuries are generally a wash, unless you have one elite player, and they go down (the year Peyton Manning was lost, and Curtis Painter was the Colts QB). But the Lions have been devastated by injuries, and still won. Starters or not, injuries or not, the Chiefs are still the champions, until someone knocks them off.
I'll take the Vikings over the Rams. Probably. The Rams are really hard to predict. If the Rams offense is in sync, and the game becomes high scoring, the Rams have a better chance. But I think the Vikings got beat this week by a damn good team, with an incredible offense. NFL.com rates the Eagles higher than the Lions in the NFC. I'm not sure what they based it on, because the Lions had a harder schedule for sure, but we may find out soon enough.
There seems to be no historical best solution to resting players. I seem to recall one year the Colts rested everyone, and looked like garbage 3 weeks later hosting the Steelers, and lost. There was another year when the Colts had a bye, but Manning played at least the first series, or first quarter of the last game of the season, to avoid rust. Not sure what happened that year (probably eventually lost to the Patriots in the playoffs!

).
Lance played as much because Rush would have achieved a $300,000 bonus if he had played and completed a few passes. Nothing more. Jerry Jones is cheap.