About the route, I'm a bit unsure what to think of it. Some of the mountain stages are better looking than most from the previous editions and there are some really nice medium mountain stages. But there are a few things about this route that really stand out to me and none of them are positives.
The Gamoniteiru mtf in particular is massively annoying me. I don't think it's a good mtf in general, it's one of those monster climbs with the steepest ramps right at the end, but I particularly dislike how it's placed. It's the final big mountain stage, so it will be in the back of the heads of the riders for almost the entire race, it comes right after another mountain stage, probably neutralizing it, yet it still comes before the only somewhat long TT of the race so some climbers might not approach this climb as aggressively as they would otherwise. It's also just so much harder than any other mtf in this vuelta (except if I'm forgetting something right now) that it will be the focus point for all gc riders going into the race. We have seen time and time again that's not a formula leading to good racing yet here we are.
The 2nd thing I really dislike is the combination of stage 20 and 21. I really like that the Vuelta decided to go for a medium mountain stage on the penultimate day again. That formula has worked really well in the past (thinking of 2015 and 2019) and this stage has a very similar appeal. In principle I'm also happy they put at least one somewhat lengthy TT in the route and I'm not against stage 21 TT's in principle either. But in this case, that TT will completely kill stage 20 and that's just a pity. It also means that Gamoniteiru becomes even more important for the climbers as they won't want to bet on an all or nothing attack on stage 20 and I think you know by now that I'm not happy about this.
Then lastly, it feels like there are more really flat stages than usually. Don't know if my memory is deceiving me since I don't think many others have criticized that aspect, but for the gt that makes a huge fuzz about having hardly any pure sprint stages, this route as quite a lot of pure sprint stages. Now I don't need a big mountain stage every day, but imo the fact that almost every day had the potential of catching a gc rider off guard has been the main appeal for the Vuelta lately, as the mountain stages themselves are usually rather underwhelming. I think I counted something like 7 stages which I would expect to end in a bunch sprint and that's just a tad much for me.