python said:
obviously de mondenard has earned the right to look down on the clinic pseudoscience.
I agree. But he doesn’t look good when he ignores the basic issue.
I wonder if de Mondenard even read the RFEC decision. I tend to think he didn’t, because if he had, he would have discovered that everyone, including Bert’s own lawyers, agrees that Bert’s CB could not have resulted from eating meat that passed the Spanish inspection standard (100 ng/kg).
That’s why they began their attempted rebuttal of WADA’s pharmacokinetic argument (based on data and discussions with the manufacturers of CB; I guess Python regards these people as pseudoscientists) by an estimation of how much CB Bert could have ingested eating meat from a steer doped with CB then allowed to withdraw (“retirado”) for a variable period of time. If you believe someone can test at Bert’s level from eating meat that passes the inspection standard, the whole “retirado” argument is beside the point. The entire argument is based on the notion that the steer is doped to the gills, then allowed to pass some of the CB before being slaughtered. It assumes that the meat is going to be over the inspection limit and somehow avoid detection. It only establishes that if it does avoid detection, there could be enough CB remaining from the original dosage to the cattle to result in Bert’s positive.
That’s also why Bert’s laywers made an elaborate (though flawed) argument intended to show that despite the lack of a single CB-positive sample of meat among tens of thousands tested in Spain, it was still possible that such a contaminated sample could have turned up in Basque country, which provided relatively few samples.
It’s also why they later claimed that the brother of someone who might have supplied Bert’s meat was busted years ago for doping cattle.
It’s also why some have argued that Bert might have eaten meat that was imported from Mexico or some South American country where standards are lax, and why (because imported meat must also pass the same standard) these supporters have also suggested that there could have been bribery, allowing the contaminated meat to be sold in Spain.
All of these points have been raised to support the claim that Bert could have eaten contaminated meat. Because—to repeat and emphasize—
meat that passes the Spanish inspection system does not have enough CB to account for Bert’s positive. The prosecution provided arguments to back up this claim at the RFEC hearing, and
Bert’s lawyers never even attempted to refute them.
OK? Everyone understand that? So what is the point of feeding volunteers contaminated meat and determining their CB levels (as DeMondenard suggests)? We already know—Bert’s team has already conceded—that if the level of CB is below the inspection standard, the result will be a lower level than what Bert tested for. All this proposed study can possibly show is how much above the inspection standard meat has to be in order to account for Bert’s test.* But this is irrelevant. Once you accept that the meat must have been above the inspection limit, the only thing that is relevant is how likely it is that Bert could have eaten such contaminated meat, however far above the standard it was. That is a matter of testing statistics, such as those provided by the prosecution at RFEC, and also of the kind I suggested.
So DeMondenard’s suggestion, while it might be useful for future cases of CB positives, is completely irrelevant to Bert’s case. I won’t call it pseudoscience. It’s just the wrong answer to the question.
*WADA provided a range of estimates for this in the RFEC report. Here is a simple argument that provides a minimum estimate. The actual test data in the RFEC report showed that Bert was positive for CB for at least four days. Using the concentrations given there, and assuming he passed a typical 1.5 liters of urine a day, we can estimate that Bert passed about 150 ng of CB in those four days. But he must have ingested a lot more than this, because it’s known that CB excretion exhibits second order kinetics, i.e., after an initial rapid phase of elimination, there is a much slower rate. A study by Yamamoto et al (1985), linked and discussed here previously, found that only about 20% of a single CB dose taken orally was eliminated after three days. Applying this to Bert’s data, he ingested a minimum of 650 ng of CB.
I don’t know how much meat Bert ate—the RFEC report only says “two fillets”—but I think 12 oz. (about 340 g) would be a reasonable maximum estimate. It could be more, but probably not a great deal more. This amount of steak provides about 650-700 calories. GT riders eat a ton of food—6000-8000 calories a day—and perhaps 3000-4000 of these might have been consumed at dinner. This would provide 15-25% of the calories in the form of animal protein. (Edit: actually a little less, because about a third of the calories in a typical steak come from fat).
If he ate 340 g of meat and consumed 650 ng of CB, the steak would contain about 1900 ng/kg, which is 19 times the limit. If you assume that more than 20% is eliminated in three days you could lower this, but even if you assume all if it was eliminated in the four days for which actual test data were available, you would get a value of over 400 ng/kg. This value could be lowered further by assuming Bert ate more than 12 oz of meat, and/or by assuming a smaller volume of urine. In fact, in the RFEC report WADA provided a value of 312 ng/kg as the lowest possible estimate, and 11,000 ng/kg as the highest estimate. The low value suggests to me that my estimate of 340 g of meat is in the right ballpark (presumably WADA has a better idea of how much meat Bert ate than I do), and the huge range indicates they were being extremely liberal with assumptions in both directions, trying to cover every possible variable or uncertainty.
As I have discussed here before, even Mexican meat bought off the street rarely reaches levels of contamination this high. In fact, from this calculation, we can see that the five Mexican players who were recently cleared from a CB positive probably did not ingest the CB from contaminated meat, either. All but three of the total of nine players reported positive had higher levels of CB in the urine than Bert, in some cases far higher. For example, one of the
lower values reported was 200 pg/ml. Assuming that level was recorded within 24 hours of ingestion (which would result in a minimum estimate of CB ingested; if the level was recorded several days later, the estimate would be considerably higher), that would correspond to a total of about 2500 ng or 2.5 ug CB ingested. For a 12 oz steak, the contamination would be about 7.5 ug/kg. This is extremely high, and though I’m sure there is meat in Mexico this contaminated, studies suggest it is quite rare. Not to mention that one of the players tested at a level more than 20 times higher than this.