Official Lance Armstrong Thread: Part 3 (Post-Confession)

[Merckx index]

As for peptides, it's a long time since I did amino acid chemistry but yes, I seem to remember they are relatively easy to make as long as they are small so conformation does not come into it. amino acids can also be bought very cheaply through Sigma Aldrich or similar suppliers. Perfectly possible someone if producing those...

Actually, you can just order short peptides custom synthesized from a lab. Just specify the sequence you want, e.g., L-A-N-C-E (lysine-alanine-asparagine-cysteine-glutamic acid), C-H-R-I-S (cysteine-histidine-arginine-isoleucine-serine) or W-I-G-G-Y (tryptophan-isoleucine-glycine-glycine-tyrosine).

 

[RownhamHill]

Should we expect a Twit pic anytime soon with Lance in the rec room and the award on the wall?

Dave.

Lance. I know you read the clinic. Please do as D-Queued suggests and tweet this, it would be such fun. . .

 

[King Boonen]

Actually, you can just order short peptides custom synthesized from a lab. Just specify the sequence you want, e.g., L-A-N-C-E (lysine-alanine-asparagine-cysteine-glutamic acid), C-H-R-I-S (cysteine-histidine-arginine-isoleucine-serine) or W-I-G-G-Y (tryptophan-isoleucine-glycine-glycine-tyrosine).

Good point. Although I would assume there are restrictions on ones that are known to be biologically active?


We see a huge number of possible peptides in data sets, if I get chance I may start digging into some of the known ones and see if they turn up in any of them.

 

[biokemguy]

peptides

Making pharmaceutical grade peptides can be just as difficult as small molecule drugs. The purification is always the tricky part and might not be part of the patent.

If you just order your favorite peptide from a generic synthesis company, they'll probably send it to you as a powder. Knowing the formulation, dosage, and administration method for performance enhancement is a whole other ball game.

I think the current crop of dopers are probably enabled by the similar people as Lance was, and these people have access to the pharm. grade material and knowledge.

 

[Hemassist]

Making pharmaceutical grade peptides can be just as difficult as small molecule drugs. The purification is always the tricky part and might not be part of the patent.

If you just order your favorite peptide from a generic synthesis company, they'll probably send it to you as a powder. Knowing the formulation, dosage, and administration method for performance enhancement is a whole other ball game.

I think the current crop of dopers are probably enabled by the similar people as Lance was, and these people have access to the pharm. grade material and knowledge.

Just need to clear something up.

EPO is very difficult to produce because of its post-translational modifications (glycosylation). It can't be produces in bacteria like HGH & insulin or easily purified from urine/animal parts.

EPO isn't your run of the mill protein.


http://ndt.oxfordjournals.org/content/22/10/2749.full

 

[Hemassist]

Good point. Although I would assume there are restrictions on ones that are known to be biologically active?


We see a huge number of possible peptides in data sets, if I get chance I may start digging into some of the known ones and see if they turn up in any of them.

There's been a lot of mimetic peptides produced for EPO in the last 20 years, but only a few have gone to clinical trials. Most of them, like Hematide, are further modified to make them more stable in the blood stream.

Here's a nice screen that resulted in identification of EPO mimetic peptides=
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC22127/

 

[Berzin]

None of this has anything to do with Armstrong, so please-enough of this off-topic talk.

 

[Hemassist]

None of this has anything to do with Armstrong, so please-enough of this off-topic talk.

Sorry Berzin. Just wanted to clear up the difficulty of EPO production.

Conversation started to get off topic here:

I heard from reliable sources that LA was going to name names at Amgen that assisted him with "new versions" of the drug. Apparently Weisel facilitated the meetings and it's all on tape...

 

[Kennf1]

SCA filed a motion last Friday seeking to have the stay partially lifted to allow the deposition of Armstrong to go forward, even if the arbitration proceeding is temporarily stayed pending the appeal. It contends Armstrong failed to offer any evidence how he would be harmed by having the deposition fo forward, other than the usual time/expense argument.

 

[MonkeyFace]

SCA filed a motion last Friday seeking to have the stay partially lifted to allow the deposition of Armstrong to go forward, even if the arbitration proceeding is temporarily stayed pending the appeal. It contends Armstrong failed to offer any evidence how he would be harmed by having the deposition fo forward, other than the usual time/expense argument.

I wish I could use the argument that my time is too valuable every time I am asked to clean the house.

 

[Oldman]

Sorry Berzin. Just wanted to clear up the difficulty of EPO production.

Conversation started to get off topic here:

No one likes a tattler....and it was still on topic for the day.

 

[Oldman]

I wish I could use the argument that my time is too valuable every time I am asked to clean the house.

He'd have some difficulty proving his time is worth much.

 

[Archibald]

He'd have some difficulty proving his time is worth much.

especially laying on the couch looking at a t-shirt collection

 

[Zam_Olyas]

Race Radio ‏@TheRaceRadio 17m
Armstrong names some of his doping suppliers and transporters http://www.scribd.com/doc/217378724/Name-Names … Told Carmichel in 95. Gorski and Weisel knew too

Race Radio ‏@TheRaceRadio 28m
Armstrong starts naming names Marti, Celaya, del Moral, Ferrari, O'Reilly, de Vriese, Maire, Weisel http://www.usatoday.com/story/sport...g-named-names-written-answers-doping/7532825/ …

 

[42x16ss]

Now we might be getting somewhere! Come on Lance, chuck the Hog under the bus too while you're there.

 

[Fatclimber]

Throwing Emma under the bus out of spite or was she really a contributor? Most likely she was in on it, but how can anybody like Armstrong's (their) credibility?

"told" Carmichael about his doping? Maybe he was even second rate at doping and therefore out of the loop.

 

[42x16ss]

I think he admitted to using O'Reilly as a courier.

 

[Gregga]

Race Radio ‏@TheRaceRadio 17m
Armstrong names some of his doping suppliers and transporters http://www.scribd.com/doc/217378724/Name-Names … Told Carmichel in 95. Gorski and Weisel knew too

This one is already full of bs : Armstrong saying he didn't use EPO after 1999 and "just" blood bags ? So, why is there EPO in your Tour of Switzerland samples, dude ?

 

[webvan]

He probably means he didn't actually take EPO doses DURING the races, which is consistent with the move to transfusions starting in 2000.

 

[JRanton]

I think he admitted to using O'Reilly as a courier.

Yes and Emma has already admitted to this on numerous occasions. Where have you guys been...

 

[42x16ss]

Yes and Emma has already admitted to this on numerous occasions. Where have you guys been...

Just saying that Armstrong wasn't really "throwing O'Reilly under the bus" just admitting to something that was already known.

 

[del1962]

Armstrong has not paid or offered to pay someone to keep his or others' doping a secret," he stated. "However, Armstrong has, on occasion, provided benefits or made contributions to many people and institutions, some of whom may have been aware of, or suspected Armstrong's use of performance-enhancing drugs and banned methods

He never extended his benefits to Flandis

 

[D-Queued]

Armstrong has not paid or offered to pay someone to keep his or others' doping a secret," he stated. "However, Armstrong has, on occasion, provided benefits or made contributions to many people and institutions, some of whom may have been aware of, or suspected Armstrong's use of performance-enhancing drugs and banned methods

...

That is coming pretty close to admitting a nod, nod, wink, wink payoff arrangement.

Also coming pretty close to admitting the hospital incident.

If we give him long enough, he may actually tell the truth.

Dave.

 

[DirtyWorks]

That is coming pretty close to admitting a nod, nod, wink, wink payoff arrangement.

Also coming pretty close to admitting the hospital incident.

If we give him long enough, he may actually tell the truth.

Dave.

Nope. Doesn't need to. That was a masterfully worded non-admission-admission he did pay off the hospital to have witnesses disappear.

Interesting that it appears he well and truly seems to recall some filtered-through-lawyers facts.

Armstrong also refers to his cycling team's general mananger, Mark Gorski, and former cyclist Chris Carmichael in his answers in the Acceptance case.

"As for Mr. Gorski, it is Armstrong's belief that he was aware of doping by the USPS team," Armstrong states. "Mr. Armstrong told Chris Carmichael in 1995 of his use of PEDs."

Mark Gorski is another fraudster that got off clean.

 

[Samson777]

Things starts to get interesting again. One of the guys Wonderboy missed, is Ochowicz. Would be interesting to know why that is the case.