It's going to be real interesting. Yes, Valverde is the only real specialist in the group of GC guys for this type of climb, so he should have the advantage, but the question is of course how sharp he is after 2 years off. He looks leaner though, so I'd expect his prologue (which would have left him farther back had he not had good weather) to suffer more than his climbing. He should be good, but we won't know until the climb.
Wiggins has never, ever shown well on a climb like this, but he's also never looked as strong as he has in the last few days, in my opinion. Leipheimer isn't suited to this type of climb either, but he's expert at a) limiting his losses and b) annoyingly exceeding expectations when he's in good form. Van Garderen has never shown anything to suggest he's really top tier at this stuff, so I don't expect anything from him, but that won't stop me from hoping his breakout performance is around the corner.
Should be a good one.