Re: Re:
If you haven't already read this paper, you might find it interesting on the testing protocols:
J Physiol Pharmacol. 2014 Aug;65(4):469-76.
Metabolic modulators of the exercise response: doping control analysis of an agonist of the peroxisome proliferator-activated receptor δ (GW501516) and 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR).
Pokrywka A1, Cholbinski P, Kaliszewski P, Kowalczyk K, Koncza
http://www.ncbi.nlm.nih.gov/pubmed/25179079
ColonelKidneyBeans said:Ryo Hazuki said:source for the 150.000 dollar? according to dr ferrari it could be traced and was useless in it's stimulant effects. I don't think anyone would use it if even doping doctors advice against itsniper said:In 2011 an Aicar treatment for a procyclist was rumored to cost around 150.000 dollar.
Yes, expensive.
What the current price is, I have no idea.
Ferrari has said many things, some truthful, some blatant lies and many whose truthfulness value lies in between...
Concerning AICAR testing, only cologne seems to have a working test, and i'm not sure about it's practicality. AICAR is an endogenous molecule, and one that does not seem incredibly complex at first glance. It's not like EPO where there's subtle difference between the human version and the exogenous version (EPO is a very big glycoprotein, if i'm not mistaken there's even some variation in the endogenous forms of it) and you can "just" use some form of chromatography or electrophoresis to separate them.
I don't know about AICAR, maybe a isotope carbone ratio test would work, but it's quite expensive.
So they probably would end up with a "working" test just like the testo test (not exactly the same mechanism,but for the sake of example), where you set a threshold and use the expensive test when the athlete exceed it. Since it will probably be set high, that's leaving plenty of room to microdose... Or manipulation by bypassing the threshold and going straight to te second test with certain athletes... Ok a bit of conspiracy but remember the Verbruggen quote...
Working on a molecule still in clinical trials might not help them too...
If you haven't already read this paper, you might find it interesting on the testing protocols:
J Physiol Pharmacol. 2014 Aug;65(4):469-76.
Metabolic modulators of the exercise response: doping control analysis of an agonist of the peroxisome proliferator-activated receptor δ (GW501516) and 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR).
Pokrywka A1, Cholbinski P, Kaliszewski P, Kowalczyk K, Koncza
http://www.ncbi.nlm.nih.gov/pubmed/25179079