- Mar 16, 2009
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+1.......................The Hitch said:I hope WonderLance comes to make a comment while the scandal is still fresh.
+1.......................The Hitch said:I hope WonderLance comes to make a comment while the scandal is still fresh.
Thoughtforfood said:It was.
However, I notice you ignored the half life argument. It doesn't seem illogical at all to think he doped in training with Clen considering it is out of the body in less than 39 hours. And unless I completely misunderstand human physiology (which could be the case), levels of the substance would diminish over time, meaning the tiny amount could be at the far end of the time line.
Following a “therapeutic dose (20, 40 and 80 micrograms/man) of clenbuterol hydrochloride”, “plasma levels of clenbuterol reached the maximum value of 0.1, 0.2 and 0.35 ng/ml, respectively, in a dose-dependent manner within 2.5 h, which lasted for over 6 h after the administration. The half-life of clenbuterol in plasma was estimated to be about 35 h.” Further only “about 20%” appears in the urine if one collects the urine cumulatively for 72 hours following a single oral dose.
icefire said:Interview with Astana's cook from 23rd of July 2010:
http://www.sport.es/default.asp?idpublicacio_PK=44&idioma=CAS&idtipusrecurs_PK=7&idnoticia_PK=722519
Last paragraph: during the three days they were at the Novotel in Lescar (next to Pau) he wasn't allowed to use the hotel kitchen. He had to make it do with a kitchen in a van. He went to the market at Pau to buy meat. No comment about French meat quality and no mention of meat coming from Spain.
Polish said:Making these PR statements is very different from actually following through. If the AFLD etc called his bluff, Alberto could say "I want to allow you, but my lawyers and Fran insist that I do NOT sign the release. Darn lawyers, Sorry"
I also seem to remember Basso giving permission to look at DNA/Puerto data to some agency group that he knew would not / could not inspect.
And they did not.
But some other agency got him in the end.
meandmygitane said:+2 for digging this up.. another piece in the puzzle of guilt.
131313 said:I didn't ignore it, I just didn't want to repeat myself or bore anyone to death.
It's certainly not "out of the body" by any means in 36 hours. Obviously it depends on the original dose. If he were using it to build mass and/or decrease adiposity, he'd have taken somewhere along the lines of 100mg. If the standard test is 10,000 pg/ml, he would have had to avoid testing for roughly 4 month to 6 months. This is taking into account degradation on stored blood (which is actually minimal) and the fact that it's a urine test. Remember, 100mg=100 million pg!
Does that seem at all reasonable?
I'm all for busting the guy. I just would like to see him getting busted for the correct offense.
Thoughtforfood said:Okay, that does sound reasonable. So you are certain that he could not have used Clenbuterol and received that reading?
robow7 said:Has this interview from the NY Times come up yet?
"Clenbuterol is banned for use in livestock in Europe and the United States. Although the drug has been used to encourage muscle growth in animals like cows and pigs, European and American regulators cracked down on the practice about 10 years ago after several clenbuterol-poisoning cases in Spain, France and Italy.
In most of those cases, the victims fell ill after eating the animals’ liver, where clenbuterol is known to accumulate.
Fernando Ramos, a professor at the University of Coimbra in Portugal who has studied clenbuterol contamination in meat for 20 years, said it was highly unlikely that Contador tested positive from eating meat other than liver, noting that the concentration would have to be so high that the animal would have died before being slaughtered.
When asked what the chances were that Contador’s positive test, even at such low levels, was a result of the meat he ate, Ramos said, “I can say 99 percent, it’s impossible"
Gosh, you beat me to it. I was getting ready to post it. This is really good evidence the Contador is lying..robow7 said:Has this interview from the NY Times come up yet?
"...
Fernando Ramos, a professor at the University of Coimbra in Portugal who has studied clenbuterol contamination in meat for 20 years, said it was highly unlikely that Contador tested positive from eating meat other than liver, noting that the concentration would have to be so high that the animal would have died before being slaughtered.
When asked what the chances were that Contador’s positive test, even at such low levels, was a result of the meat he ate, Ramos said, “I can say 99 percent, it’s impossible"
A few more thoughts on clenbuterol pharmacokinetics but first, full disclosure: I posted the section pasted above in "The tablet theory" - my name and affiliation are:
Robert G. Thorne, PhD, Assistant Professor, Division of Pharmaceutical Sciences, University of Wisconsin-Madison
The views I have are of course my own and do not represent that of my employer, the University of Wisconsin.
The point I would like to make is that the initial coverage of this story in the press based upon some of the official documents released thus far by the UCI and Contador's scientific expert have led to the idea that the levels of clenbuterol in Contador's urine are so low as to call into question that they would be associated with any benefit. I don't agree with that. One reason the levels may be so low is that professional cyclists who choose to use performance enhancers in today's races, with the biological passport and increasingly sophisticated testing, must likely do so with the idea that the performance gains they may achieve while still avoiding detection are much less than those of the past. So the level of 'enhancement' we are likely still witnessing is subtle, as Drs. Tucker and Dugas have commented many times already. To reference clenbuterol levels of past dopers and say that Contador's level is '500 to 1000 times less than the doses found in doping cases' (Professor Michel Audran, Velonation report, Sept 30, 2010) seems not to acknowledge this new reality in professional sports that take testing seriously. I do not know whether Contador transfused blood with clenbuterol, took a tablet or ate contaminated beef, but I do know that all this talk about the levels being too low to matter and that somehow this may help point to his innocence is just not convincing.
LOL. 60% in some cases.Moose McKnuckles said:That percentage rises to 53% if the meat belongs to a professional cyclist.
Wow. I had not seen your comment. Thanks. I had used 20% in my calculations. Now they say that you can only get contaminated if you eat liver. LOL.roundabout said:Nah, Contador's luck just ran out since there's indeed a 0.044% chance of finding meat positive for clenbutarol in Europe.
Escarabajo said:From Science of the Sports. From the comments section on today's article:
I thought it was interesting that still a direct consumption of the product is possible.![]()
samerics said:He tested for a bloody huge dose of it after a day when he took 9 minutes or more out of people who kicked his *** the day before! Come on...
auscyclefan94 said:WE WILL SCREW THE SAINTS RIGHT UP TOMMOROW!
Jamsque said:Unless they can get some cattle farmer to testify that he deliberately broke EU farming legislation and fed his cows a banned substance I don't see how anything is going to come to light that will help Contador's story seem more credible.
The two biggest misconceptions in this thread are first that the contaminated meat story is plausible, which it isn't, since feeding Clen to animals is banned in the EU and (as an earlier poster pointed out) there hasn't been a recorded case of contamination in Europe for fourteen years, and second that were this story to be accepted as true Contador might be able to get a reduced sentence, which he can't, since the rules very clearly state that all athletes are responsible for whatever is found in their samples regardless of how it got there. The rules are completely unambiguous on this point. He had a banned substance in his body, so he should be banned, whether it got there through a blood transfusion or a steak or magical Clenbutarol faeries is irrelevant.
To justify any elimination or reduction, the License-Holder must produce corroborating evidence in addition to his word which establishes to the comfortable satisfaction of the hearing panel the absence of an intent to enhance sport performance or mask the use of a performance enhancing substance. The License-Holder’s degree of fault shall be the criterion considered in assessing any reduction of the period of Ineligibility.
yep, thank you.roundabout said:
robow7 said:Has this interview from the NY Times come up yet?
"Clenbuterol is banned for use in livestock in Europe and the United States. Although the drug has been used to encourage muscle growth in animals like cows and pigs, European and American regulators cracked down on the practice about 10 years ago after several clenbuterol-poisoning cases in Spain, France and Italy.
In most of those cases, the victims fell ill after eating the animals’ liver, where clenbuterol is known to accumulate.
Fernando Ramos, a professor at the University of Coimbra in Portugal who has studied clenbuterol contamination in meat for 20 years, said it was highly unlikely that Contador tested positive from eating meat other than liver, noting that the concentration would have to be so high that the animal would have died before being slaughtered.
When asked what the chances were that Contador’s positive test, even at such low levels, was a result of the meat he ate, Ramos said, “I can say 99 percent, it’s impossible"
roundabout said:You mean this one
http://www.elpais.com/articulo/depo...ar/Contador/elpepidep/20101002elpepidep_2/Tes
I still can't get over the shock.![]()