Leading GB cyclist tests positive (yikes)!

[sniper]

Re:

Apologies for misleading anyone, I was looking at sites like http://www.rxlist.com/terbutaline-sulfate-side-effects-drug-center.htm

Brand names Brethine, Bricanyl, Brethaire are no longer available in the U.S

and http://www.medicinenet.com/terbutaline/index.htm

Terbutaline (Brethine, Bricanyl, and Brethaire are no longer available in the U.S.)

which does leave it possible that it's available as a generic or off-label or whatever. After more searching I found this NIH (the American National Institute of Health, so I'd consider it quite authoritative) link https://www.nlm.nih.gov/medlineplus/druginfo/meds/a682144.html

This branded product is no longer on the market. Generic alternatives may be available.

Interestingly from the same link:

Terbutaline comes as a tablet to take by mouth. The tablets are usually taken three times a day, once every six hours.

The reason inhalers were invented was to get the drug directly to where it's needed, in the lungs, so the minimum dose can be used, avoiding side effects in other parts of the body. Now according to this link http://www.fiercepharma.com/special-report/top-20-generic-molecules-worldwide salbutamol is the 15th highest selling generic drug of any kind in the world. It's available by inhaler, to minimise side effects, and doesn't need a TUE. So why take a banned pill?

well done, excellent.

seems "non common asthma medication" wasn't far off.

 

[Eshnar]

Re:

Interestingly from the same link:

Terbutaline comes as a tablet to take by mouth. The tablets are usually taken three times a day, once every six hours.

The reason inhalers were invented was to get the drug directly to where it's needed, in the lungs, so the minimum dose can be used, avoiding side effects in other parts of the body. Now according to this link http://www.fiercepharma.com/special-report/top-20-generic-molecules-worldwide salbutamol is the 15th highest selling generic drug of any kind in the world. It's available by inhaler, to minimise side effects, and doesn't need a TUE. So why take a banned pill?

Terbutaline also comes in inhalers (Brethaire is one). Pills and injections as well. Pretty much everything.

 

[hrotha]

Re:

The reason inhalers were invented was to get the drug directly to where it's needed, in the lungs, so the minimum dose can be used, avoiding side effects in other parts of the body. Now according to this link http://www.fiercepharma.com/special-report/top-20-generic-molecules-worldwide salbutamol is the 15th highest selling generic drug of any kind in the world. It's available by inhaler, to minimise side effects, and doesn't need a TUE. So why take a banned pill?

I imagine Orica's official story is that it wasn't a pill, but an inhaler. Apparently it's available as both, and only the use as an inhaler (& with a TUE) is allowed by WADA.

 

[Benotti69]

British cyclist Simon Yates won't be provisionally suspended despite failing a drugs test. UKAD

 

[gillan1969]

yup...struggling so much with his breathing he was 5th on the stage...pretty hectic stage from memory

must be a nightmare struggling with that condition

http://www.cyclingnews.com/paris-nice/stage-7/results/

opening paragraph is funny...Thomas was 'breathless'

 

[Benotti69]

Re: Re:

The reason inhalers were invented was to get the drug directly to where it's needed, in the lungs, so the minimum dose can be used, avoiding side effects in other parts of the body. Now according to this link http://www.fiercepharma.com/special-report/top-20-generic-molecules-worldwide salbutamol is the 15th highest selling generic drug of any kind in the world. It's available by inhaler, to minimise side effects, and doesn't need a TUE. So why take a banned pill?

I imagine Orica's official story is that it wasn't a pill, but an inhaler. Apparently it's available as both, and only the use as an inhaler (& with a TUE) is allowed by WADA.

WADA requires explanation to why a rider uses Terbutaline rather than Salbutamol.

 

[Irondan]

Appears he's needed this med for a long time.

Here come the troops!

 

[SeriousSam]

Just to clarify salbutamol is the generic name for the drug and ventolin is the brand name. Terbutaline is a commonly prescribed drug for asthma even if not widely used by cyclists.

I do find it very odd that so many athletes have asthma. It seems too convenient.

it is not "odd", it is just a joke. A very old one.

EDIT: Welcome to the forum btw.

Why do so many athletes have asthma?
http://www.theguardian.com/sport/2016/apr/29/elite-athletes-asthma-simon-yates-team-sky-swimmers

John Dickinson from Kent University’s school of sport & exercise sciences, a world expert on asthma in sport, tested all 33 UK-based members of the British swimming squad and found 70% had some form of asthma, against a national asthma rate of about 8% to 10%. It is believed the chlorinated atmosphere of a pool could be a factor in this.

 

[thehog]

yup...struggling so much with his breathing he was 5th on the stage...pretty hectic stage from memory

must be a nightmare struggling with that condition

http://www.cyclingnews.com/paris-nice/stage-7/results/

opening paragraph is funny...Thomas was 'breathless'

Yes, he rode well that day. Must have been hard with his asthma attack that he had throughout the stage

 

[Benotti69]

Re:

Appears he's needed this med for a long time.

Here come the troops!

Picture Russian athlete posting similar about Sharapova

 

[thehog]

Re:

Appears he's needed this med for a long time.

Here come the troops!

What I find odd is Yates dropped Goss's inhaler, then OGR start asking teams for one of there's... didn't Yates have one to provide if he asthma?

 

[Benotti69]

Simon Yates is a hero to asthma sufferers world wide.

 

[luckyboy]

Just to clarify salbutamol is the generic name for the drug and ventolin is the brand name. Terbutaline is a commonly prescribed drug for asthma even if not widely used by cyclists.

I do find it very odd that so many athletes have asthma. It seems too convenient.

it is not "odd", it is just a joke. A very old one.

EDIT: Welcome to the forum btw.

Why do so many athletes have asthma?
http://www.theguardian.com/sport/2016/apr/29/elite-athletes-asthma-simon-yates-team-sky-swimmers

John Dickinson from Kent University’s school of sport & exercise sciences, a world expert on asthma in sport, tested all 33 UK-based members of the British swimming squad and found 70% had some form of asthma, against a national asthma rate of about 8% to 10%. It is believed the chlorinated atmosphere of a pool could be a factor in this.

Just been speaking to him on the phone. Says that it's on the milder end of the asthma spectrum, only occurs at top end of their high intensity exercise, unlikely to suffer when not training or competing.

 

[Irondan]

British cyclist Simon Yates has not been provisionally suspended for failing a drug test at Paris-Nice in March, which his Australian team Orica – GreenEdge blamed on an “administrative error” during treatment for asthma. The drug in question, terbutaline, does not appear on the World Anti-Doping Agency’s prohibited list.
Read more at http://velonews.competitor.com/2016/04/news/yates-avoids-provisional-suspension-after-anti-doping-positive_403983#c2wl0XfAva8bVXYL.99

If it's not banned, why would this be an AAF?

 

[King Boonen]

Re: Re:

Apologies for misleading anyone, I was looking at sites like http://www.rxlist.com/terbutaline-sulfate-side-effects-drug-center.htm

Brand names Brethine, Bricanyl, Brethaire are no longer available in the U.S

and http://www.medicinenet.com/terbutaline/index.htm

Terbutaline (Brethine, Bricanyl, and Brethaire are no longer available in the U.S.)

which does leave it possible that it's available as a generic or off-label or whatever. After more searching I found this NIH (the American National Institute of Health, so I'd consider it quite authoritative) link https://www.nlm.nih.gov/medlineplus/druginfo/meds/a682144.html

This branded product is no longer on the market. Generic alternatives may be available.

Interestingly from the same link:

Terbutaline comes as a tablet to take by mouth. The tablets are usually taken three times a day, once every six hours.

The reason inhalers were invented was to get the drug directly to where it's needed, in the lungs, so the minimum dose can be used, avoiding side effects in other parts of the body. Now according to this link http://www.fiercepharma.com/special-report/top-20-generic-molecules-worldwide salbutamol is the 15th highest selling generic drug of any kind in the world. It's available by inhaler, to minimise side effects, and doesn't need a TUE. So why take a banned pill?

well done, excellent.

seems "non common asthma medication" wasn't far off.

More perpetuation of absolute rubbish. FDA approval:

http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction=Search.Overview&DrugName=TERBUTALINE%20SULFATE

MHRA current prescribing advice where terbutaline is listed as an often prescribed short acting beta 2 agonist:

https://www.gov.uk/government/publications/asthma-long-acting-ss2-agonists-use-and-safety/asthma-long-acting-ss2-agonists-use-and-safety

MHRA approved terbutaline products including large numbers of inhalers:

http://www.mhra.gov.uk/spc-pil/?subsName=TERBUTALINE%20SULPHATE&pageID=SecondLevel

Australian Register of Therapeutic Goods for terbutaline inhaler from 1991:

https://www.ebs.tga.gov.au/servlet/xmlmillr6?dbid=ebs/PublicHTML/pdfStore.nsf&docid=1F35BC7AD4DC71FFCA257EEE003CA720&agid=(PrintDetailsPublic)&actionid=1

New Zealand Medicines and Medical Devices Safety Authority (MEDSAFE) minutes from their 7th meeting in 1990 detailing that terbutaline is already approved

http://www.medsafe.govt.nz/profs/class/Minutes/1984-1990/7thmeeting/7th-MCC-Minutes-Medicines-Considered.pdf

Paper from 1970 when it could actually be considered "new":

https://www.ncbi.nlm.nih.gov/pubmed/4396159

Paper from 1970 detailing a clinical comparison involving inhaled terbutaline:

https://www.ncbi.nlm.nih.gov/pubmed/5508406

DrugBank entry for terbutaline:

http://www.drugbank.ca/drugs/DB00871

 

[King Boonen]

Re:

British cyclist Simon Yates has not been provisionally suspended for failing a drug test at Paris-Nice in March, which his Australian team Orica – GreenEdge blamed on an “administrative error” during treatment for asthma. The drug in question, terbutaline, does not appear on the World Anti-Doping Agency’s prohibited list.
Read more at http://velonews.competitor.com/2016/04/news/yates-avoids-provisional-suspension-after-anti-doping-positive_403983#c2wl0XfAva8bVXYL.99

If it's not banned, why would this be an AAF?

I can't see that quote in the text, but it is very wrong. It does appear as it is a beta-2 agonist:

S3. BETA-2 AGONISTS
All beta-2 agonists, including all optical isomers, e.g. d- and l- where relevant, are prohibited.

 

[sniper]

Re:

Appears he's needed this med for a long time.

Here come the troops!

Yikes, it takes quite the effort to insult that quarter of a brain of mine.
Props to this guy for making that look easy.

 

[gillan1969]

Re: Re:

Appears he's needed this med for a long time.

Here come the troops!

Yikes, it takes quite the effort to insult that quarter of a brain of mine.
Props to this guy for making that look easy.

yup really struggled to that 5th on the stage

 

[Irondan]

Re: Re:

British cyclist Simon Yates has not been provisionally suspended for failing a drug test at Paris-Nice in March, which his Australian team Orica – GreenEdge blamed on an “administrative error” during treatment for asthma. The drug in question, terbutaline, does not appear on the World Anti-Doping Agency’s prohibited list.
Read more at http://velonews.competitor.com/2016/04/news/yates-avoids-provisional-suspension-after-anti-doping-positive_403983#c2wl0XfAva8bVXYL.99

If it's not banned, why would this be an AAF?

I can't see that quote in the text, but it is very wrong. It does appear as it is a beta-2 agonist:

S3. BETA-2 AGONISTS
All beta-2 agonists, including all optical isomers, e.g. d- and l- where relevant, are prohibited.

Velonews has since edited their article apparently...

Seems they were wrong.

British cyclist Simon Yates has not been provisionally suspended for failing a drug test at Paris-Nice in March, which his Australian team Orica – GreenEdge blamed on an “administrative error” during treatment for asthma.
Read more at http://velonews.competitor.com/2016/04/news/yates-avoids-provisional-suspension-after-anti-doping-positive_403983#xzsI0gZfJiAGoOhb.99

 

[King Boonen]

Re: Re:

British cyclist Simon Yates has not been provisionally suspended for failing a drug test at Paris-Nice in March, which his Australian team Orica – GreenEdge blamed on an “administrative error” during treatment for asthma. The drug in question, terbutaline, does not appear on the World Anti-Doping Agency’s prohibited list.
Read more at http://velonews.competitor.com/2016/04/news/yates-avoids-provisional-suspension-after-anti-doping-positive_403983#c2wl0XfAva8bVXYL.99

If it's not banned, why would this be an AAF?

I can't see that quote in the text, but it is very wrong. It does appear as it is a beta-2 agonist:

S3. BETA-2 AGONISTS
All beta-2 agonists, including all optical isomers, e.g. d- and l- where relevant, are prohibited.

Velonews has since edited their article apparently...

Seems they were wrong...

At least they can admit it...

 

[simoni]

yup...struggling so much with his breathing he was 5th on the stage...pretty hectic stage from memory

must be a nightmare struggling with that condition

http://www.cyclingnews.com/paris-nice/stage-7/results/

opening paragraph is funny...Thomas was 'breathless'

Yes, he rode well that day. Must have been hard with his asthma attack that he had throughout the stage

Just a thought but maybe the drug, you know, worked?!

PS - He should get a ban here - I see no other reasonable possibility.

 

[hrotha]

Just a thought but maybe the drug, you know, worked?!

Oh it worked alright

 

[sniper]

Re: Re:

Appears he's needed this med for a long time.

Here come the troops!

Yikes, it takes quite the effort to insult that quarter of a brain of mine.
Props to this guy for making that look easy.

yup really struggled to that 5th on the stage

from Doull's wiki:
"In November 2015 Owain Doull confirmed that he would remain at WIGGINS for the 2016 season before joining an unnamed UCI WorldTeam on a two-year deal from 2017"
Orica by any chance?

 

[sniper]

Re: Re:

snipped for brevity

thanks for the trouble.
tbs, the problem i have is with the "clearly false and made up" label. It may have been made up, but not by Benotti. I had seen tweets suggesting similar.
Seems it's not so straightforward.

 

[vedrafjord]

Re: Re:

More perpetuation of absolute rubbish. FDA approval:

http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction=Search.Overview&DrugName=TERBUTALINE%20SULFATE

From your own link (I've combined the different trade names into one table):

Drug Name Dosage Form/Route Strength Marketing Status Company
TERBUTALINE SULFATE TABLET;ORAL  Multiple Strengths  Discontinued IMPAX LABS
TERBUTALINE SULFATE INJECTABLE;INJECTION  1MG/ML  Prescription BEDFORD
TERBUTALINE SULFATE INJECTABLE;INJECTION  1MG/ML  Discontinued TEVA PHARMS USA
TERBUTALINE SULFATE INJECTABLE;INJECTION  1MG/ML  Prescription FRESENIUS KABI USA
TERBUTALINE SULFATE TABLET;ORAL  Multiple Strengths  Prescription LANNETT
TERBUTALINE SULFATE INJECTABLE;INJECTION  1MG/ML  Prescription AKORN
TERBUTALINE SULFATE INJECTABLE;INJECTION  1MG/ML  Prescription HIKMA FARMACEUTICA
TERBUTALINE SULFATE INJECTABLE;INJECTION  1MG/ML  Prescription UNITED BIOMEDCL
BRETHAIRE  AEROSOL, METERED;INHALATION  0.2MG/INH  Discontinued  No
BRETHINE TABLET;ORAL  Multiple Strengths  Discontinued LEHIGH VALLEY
BRETHINE INJECTABLE;INJECTION  1MG/ML  Discontinued AAIPHARMA LLC
BRICANYL INJECTABLE;INJECTION  1MG/ML  Discontinued SANOFI AVENTIS US
BRICANYL TABLET;ORAL  Multiple Strengths  Discontinued SANOFI AVENTIS US
BRICANYL AEROSOL, METERED;INHALATION  0.2MG/INH  Discontinued SANOFI AVENTIS US

So in the USA all the inhalers are discontinued, and one company supplies tablets and five do injections.

Any other asthmatics here? What are you currently prescribed?